Salivary cytokine profile in patients with ischemic stroke

Abstract Inflammation plays a crucial role in stroke pathogenesis. Thus, it is not surprising that cytokines, chemokines, and growth factors have been advocated in stroke diagnostics. Our study is the first to evaluate the salivary cytokine profile in patients with ischemic stroke. Twenty-five patie...

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Autores principales:	Mateusz Maciejczyk, Kacper Maksymilian Mil, Piotr Gerreth, Katarzyna Hojan, Anna Zalewska, Karolina Gerreth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5016893d3611498a92c46cc4fd418b14
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spelling	oai:doaj.org-article:5016893d3611498a92c46cc4fd418b142021-12-02T15:09:15ZSalivary cytokine profile in patients with ischemic stroke10.1038/s41598-021-96739-02045-2322https://doaj.org/article/5016893d3611498a92c46cc4fd418b142021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96739-0https://doaj.org/toc/2045-2322Abstract Inflammation plays a crucial role in stroke pathogenesis. Thus, it is not surprising that cytokines, chemokines, and growth factors have been advocated in stroke diagnostics. Our study is the first to evaluate the salivary cytokine profile in patients with ischemic stroke. Twenty-five patients with subacute ischemic stroke and an age-, sex-, and oral hygiene status-matched control group were enrolled in the study. The number of patients was set a priori based on our previous experiment (α = 0.05, test power = 0.9). Salivary concentrations of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and interleukin 10 (IL-10) were assessed using an ELISA method. We showed that salivary TNF-α and IL-6 were significantly higher, whereas IL-10 content was statistically lower in both non-stimulated (NWS) and stimulated (SWS) whole saliva of ischemic stroke patients. However, evaluation of cytokines in NWS rather than in SWS may be of greater diagnostic value. Of particular note is salivary TNF-α, which may indicate cognitive/physical impairment in post-stroke individuals. This parameter distinguishes stroke patients from healthy controls and correlates with cognitive decline and severity of functional impairment. It also differentiates (with high sensitivity and specificity) stroke patients with normal cognition from mild to moderate cognitive impairment. Saliva may be an alternative to blood for assessing cytokines in stroke patients, although further studies on a larger patient population are needed.Mateusz MaciejczykKacper Maksymilian MilPiotr GerrethKatarzyna HojanAnna ZalewskaKarolina GerrethNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mateusz Maciejczyk Kacper Maksymilian Mil Piotr Gerreth Katarzyna Hojan Anna Zalewska Karolina Gerreth Salivary cytokine profile in patients with ischemic stroke
description	Abstract Inflammation plays a crucial role in stroke pathogenesis. Thus, it is not surprising that cytokines, chemokines, and growth factors have been advocated in stroke diagnostics. Our study is the first to evaluate the salivary cytokine profile in patients with ischemic stroke. Twenty-five patients with subacute ischemic stroke and an age-, sex-, and oral hygiene status-matched control group were enrolled in the study. The number of patients was set a priori based on our previous experiment (α = 0.05, test power = 0.9). Salivary concentrations of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and interleukin 10 (IL-10) were assessed using an ELISA method. We showed that salivary TNF-α and IL-6 were significantly higher, whereas IL-10 content was statistically lower in both non-stimulated (NWS) and stimulated (SWS) whole saliva of ischemic stroke patients. However, evaluation of cytokines in NWS rather than in SWS may be of greater diagnostic value. Of particular note is salivary TNF-α, which may indicate cognitive/physical impairment in post-stroke individuals. This parameter distinguishes stroke patients from healthy controls and correlates with cognitive decline and severity of functional impairment. It also differentiates (with high sensitivity and specificity) stroke patients with normal cognition from mild to moderate cognitive impairment. Saliva may be an alternative to blood for assessing cytokines in stroke patients, although further studies on a larger patient population are needed.
format	article
author	Mateusz Maciejczyk Kacper Maksymilian Mil Piotr Gerreth Katarzyna Hojan Anna Zalewska Karolina Gerreth
author_facet	Mateusz Maciejczyk Kacper Maksymilian Mil Piotr Gerreth Katarzyna Hojan Anna Zalewska Karolina Gerreth
author_sort	Mateusz Maciejczyk
title	Salivary cytokine profile in patients with ischemic stroke
title_short	Salivary cytokine profile in patients with ischemic stroke
title_full	Salivary cytokine profile in patients with ischemic stroke
title_fullStr	Salivary cytokine profile in patients with ischemic stroke
title_full_unstemmed	Salivary cytokine profile in patients with ischemic stroke
title_sort	salivary cytokine profile in patients with ischemic stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5016893d3611498a92c46cc4fd418b14
work_keys_str_mv	AT mateuszmaciejczyk salivarycytokineprofileinpatientswithischemicstroke AT kacpermaksymilianmil salivarycytokineprofileinpatientswithischemicstroke AT piotrgerreth salivarycytokineprofileinpatientswithischemicstroke AT katarzynahojan salivarycytokineprofileinpatientswithischemicstroke AT annazalewska salivarycytokineprofileinpatientswithischemicstroke AT karolinagerreth salivarycytokineprofileinpatientswithischemicstroke
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Salivary cytokine profile in patients with ischemic stroke

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