Primary Extraskeletal Myxoid Chondrosarcoma: A Case Report

Extraskeletal Myxoid Chondrosarcoma (EMC) is a rare malignant soft tissue sarcoma with uncertain differentiation, most often seen in males. The incidence is 3% of all soft tissue tumours with limited literature available on its cytological features. EMC may arise from lower extremities, upper extr...

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Autores principales:	Renuka Bangalore Nagaraj, Arshiya sultana
Formato:	article
Lenguaje:	EN
Publicado:	JCDR Research and Publications Private Limited 2021
Materias:	fine needle aspiration cytology pleomorphic myxoid sarcoma pleomorphic spindle cell Medicine R
Acceso en línea:	https://doaj.org/article/5018d117f1444f3a977fd609c831d8fb
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spelling	oai:doaj.org-article:5018d117f1444f3a977fd609c831d8fb2021-11-10T04:43:45ZPrimary Extraskeletal Myxoid Chondrosarcoma: A Case Report10.7860/JCDR/2021/47753.153192249-782X0973-709Xhttps://doaj.org/article/5018d117f1444f3a977fd609c831d8fb2021-09-01T00:00:00Zhttps://www.jcdr.net/articles/PDF/15319/47753_CE[Ra1]_F[SK]_PF1(MG_SHU)_PFA(MG_KM)_PN(KM).pdfhttps://doaj.org/toc/2249-782Xhttps://doaj.org/toc/0973-709XExtraskeletal Myxoid Chondrosarcoma (EMC) is a rare malignant soft tissue sarcoma with uncertain differentiation, most often seen in males. The incidence is 3% of all soft tissue tumours with limited literature available on its cytological features. EMC may arise from lower extremities, upper extremities, retroperitoneum, pelvis, and buttocks. This case report was an effort to understand the role of Fine Needle Aspiration Cytology (FNAC), histopathology and immunochemistry in the diagnosis of EMC. Authors hereby report a case of a 70-year-old male patient with slow-growing soft tissue swelling on the back just behind the right shoulder who was referred for FNAC. Patient complete history and clinical findings were recorded. Radiological images were suggestive of malignant soft tissue neoplasm with no involvement of underlining bone. FNAC reveled tumour cells which appeared monotonous and they were seen in a myxoid stroma background. Subsequently, the excised lesion was sent for histopathological examination and the report revealed the presence of abundant chondromyxoid matrix material within which were found numerous elongated spindly shaped cells. These cells had moderately pleomorphic elongated nuclei with focal solid fibrocollagenous areas along intersecting fascicles of the moderately pleomorphic spindly cell. Few of these cells had multilobulated bizarre nuclei with nuclear inclusions. Immunohistochemical stains showed diffuse positivity for S-100, vimentin, and focally positive for Epithelial Membrane Antigen (EMA). The FNAC, histopathology and immunohistochemical features confirm the diagnosis of EMC on right shoulder. It’s a rare tumour whose diagnosis is made depending on history, clinical location, growth pattern, histopathology, and immunohistochemistry.Renuka Bangalore NagarajArshiya sultanaJCDR Research and Publications Private Limitedarticlefine needle aspiration cytologypleomorphic myxoid sarcomapleomorphic spindle cellMedicineRENJournal of Clinical and Diagnostic Research, Vol 15, Iss 9, Pp ED01-ED03 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fine needle aspiration cytology pleomorphic myxoid sarcoma pleomorphic spindle cell Medicine R
spellingShingle	fine needle aspiration cytology pleomorphic myxoid sarcoma pleomorphic spindle cell Medicine R Renuka Bangalore Nagaraj Arshiya sultana Primary Extraskeletal Myxoid Chondrosarcoma: A Case Report
description	Extraskeletal Myxoid Chondrosarcoma (EMC) is a rare malignant soft tissue sarcoma with uncertain differentiation, most often seen in males. The incidence is 3% of all soft tissue tumours with limited literature available on its cytological features. EMC may arise from lower extremities, upper extremities, retroperitoneum, pelvis, and buttocks. This case report was an effort to understand the role of Fine Needle Aspiration Cytology (FNAC), histopathology and immunochemistry in the diagnosis of EMC. Authors hereby report a case of a 70-year-old male patient with slow-growing soft tissue swelling on the back just behind the right shoulder who was referred for FNAC. Patient complete history and clinical findings were recorded. Radiological images were suggestive of malignant soft tissue neoplasm with no involvement of underlining bone. FNAC reveled tumour cells which appeared monotonous and they were seen in a myxoid stroma background. Subsequently, the excised lesion was sent for histopathological examination and the report revealed the presence of abundant chondromyxoid matrix material within which were found numerous elongated spindly shaped cells. These cells had moderately pleomorphic elongated nuclei with focal solid fibrocollagenous areas along intersecting fascicles of the moderately pleomorphic spindly cell. Few of these cells had multilobulated bizarre nuclei with nuclear inclusions. Immunohistochemical stains showed diffuse positivity for S-100, vimentin, and focally positive for Epithelial Membrane Antigen (EMA). The FNAC, histopathology and immunohistochemical features confirm the diagnosis of EMC on right shoulder. It’s a rare tumour whose diagnosis is made depending on history, clinical location, growth pattern, histopathology, and immunohistochemistry.
format	article
author	Renuka Bangalore Nagaraj Arshiya sultana
author_facet	Renuka Bangalore Nagaraj Arshiya sultana
author_sort	Renuka Bangalore Nagaraj
title	Primary Extraskeletal Myxoid Chondrosarcoma: A Case Report
title_short	Primary Extraskeletal Myxoid Chondrosarcoma: A Case Report
title_full	Primary Extraskeletal Myxoid Chondrosarcoma: A Case Report
title_fullStr	Primary Extraskeletal Myxoid Chondrosarcoma: A Case Report
title_full_unstemmed	Primary Extraskeletal Myxoid Chondrosarcoma: A Case Report
title_sort	primary extraskeletal myxoid chondrosarcoma: a case report
publisher	JCDR Research and Publications Private Limited
publishDate	2021
url	https://doaj.org/article/5018d117f1444f3a977fd609c831d8fb
work_keys_str_mv	AT renukabangalorenagaraj primaryextraskeletalmyxoidchondrosarcomaacasereport AT arshiyasultana primaryextraskeletalmyxoidchondrosarcomaacasereport
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Primary Extraskeletal Myxoid Chondrosarcoma: A Case Report

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