H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines

Avian flu: Vaccines struggle to elicit strong immune response Evidence shows that vaccines for avian flu provoke a poorer immune response than those for seasonal human flu. Avian influenza is an emergent disease that poses a credible threat to public health, yet vaccines to treat avian flu have not...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sook-San Wong, Jennifer DeBeauchamp, Mark Zanin, Yilun Sun, Li Tang, Richard Webby
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/5018e39e40374a01bad24b96c9c8f133
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5018e39e40374a01bad24b96c9c8f133
record_format	dspace
spelling	oai:doaj.org-article:5018e39e40374a01bad24b96c9c8f1332021-12-02T16:06:13ZH5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines10.1038/s41541-017-0017-52059-0105https://doaj.org/article/5018e39e40374a01bad24b96c9c8f1332017-06-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0017-5https://doaj.org/toc/2059-0105Avian flu: Vaccines struggle to elicit strong immune response Evidence shows that vaccines for avian flu provoke a poorer immune response than those for seasonal human flu. Avian influenza is an emergent disease that poses a credible threat to public health, yet vaccines to treat avian flu have not performed well in clinical trials. A team of scientists led by Richard Webby of St Jude Children’s Research Hospital, United States, investigated the reasons for this by comparing vaccine’s ability to stimulate the immune system in comparison to a vaccine to treat seasonal human flu. In contrast to previous hypotheses, Webby’s group found that only the avian H5N1 flu vaccine provoked a lesser release of neutralizing antibodies compared to the H7N9 (another avian flu) and seasonal flu vaccine, and hypothesized that differences in viral surface proteins may account for the difference. The authors hope this helps to direct future research into vaccine-induced immunity.Sook-San WongJennifer DeBeauchampMark ZaninYilun SunLi TangRichard WebbyNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Sook-San Wong Jennifer DeBeauchamp Mark Zanin Yilun Sun Li Tang Richard Webby H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines
description	Avian flu: Vaccines struggle to elicit strong immune response Evidence shows that vaccines for avian flu provoke a poorer immune response than those for seasonal human flu. Avian influenza is an emergent disease that poses a credible threat to public health, yet vaccines to treat avian flu have not performed well in clinical trials. A team of scientists led by Richard Webby of St Jude Children’s Research Hospital, United States, investigated the reasons for this by comparing vaccine’s ability to stimulate the immune system in comparison to a vaccine to treat seasonal human flu. In contrast to previous hypotheses, Webby’s group found that only the avian H5N1 flu vaccine provoked a lesser release of neutralizing antibodies compared to the H7N9 (another avian flu) and seasonal flu vaccine, and hypothesized that differences in viral surface proteins may account for the difference. The authors hope this helps to direct future research into vaccine-induced immunity.
format	article
author	Sook-San Wong Jennifer DeBeauchamp Mark Zanin Yilun Sun Li Tang Richard Webby
author_facet	Sook-San Wong Jennifer DeBeauchamp Mark Zanin Yilun Sun Li Tang Richard Webby
author_sort	Sook-San Wong
title	H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines
title_short	H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines
title_full	H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines
title_fullStr	H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines
title_full_unstemmed	H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines
title_sort	h5n1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and h7n9 influenza vaccines
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5018e39e40374a01bad24b96c9c8f133
work_keys_str_mv	AT sooksanwong h5n1influenzavaccineinducesalessrobustneutralizingantibodyresponsethanseasonaltrivalentandh7n9influenzavaccines AT jenniferdebeauchamp h5n1influenzavaccineinducesalessrobustneutralizingantibodyresponsethanseasonaltrivalentandh7n9influenzavaccines AT markzanin h5n1influenzavaccineinducesalessrobustneutralizingantibodyresponsethanseasonaltrivalentandh7n9influenzavaccines AT yilunsun h5n1influenzavaccineinducesalessrobustneutralizingantibodyresponsethanseasonaltrivalentandh7n9influenzavaccines AT litang h5n1influenzavaccineinducesalessrobustneutralizingantibodyresponsethanseasonaltrivalentandh7n9influenzavaccines AT richardwebby h5n1influenzavaccineinducesalessrobustneutralizingantibodyresponsethanseasonaltrivalentandh7n9influenzavaccines
_version_	1718385087080300544

H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines

Ejemplares similares