Is ABO Blood Group a Predictive Factor for the Amount of Opioid Consumption in the First 24 Hours After Cesarean Section?

Sasikaan Nimmaanrat,1 Withaporn Thongkumdee,1 Alan F Geater,2 Maliwan Oofuvong,1 Pannawit Benjhawaleemas1 1Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, 90110, Thailand; 2Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hatyai...

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Autores principales:	Nimmaanrat S, Thongkumdee W, Geater AF, Oofuvong M, Benjhawaleemas P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	abo blood group predictive factors cesarean section postoperative opioid consumption Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/501b4a1f80a54c35983a6a599b120711
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spelling	oai:doaj.org-article:501b4a1f80a54c35983a6a599b1207112021-11-23T18:43:01ZIs ABO Blood Group a Predictive Factor for the Amount of Opioid Consumption in the First 24 Hours After Cesarean Section?1178-7090https://doaj.org/article/501b4a1f80a54c35983a6a599b1207112021-11-01T00:00:00Zhttps://www.dovepress.com/is-abo-blood-group-a-predictive-factor-for-the-amount-of-opioid-consum-peer-reviewed-fulltext-article-JPRhttps://doaj.org/toc/1178-7090Sasikaan Nimmaanrat,1 Withaporn Thongkumdee,1 Alan F Geater,2 Maliwan Oofuvong,1 Pannawit Benjhawaleemas1 1Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, 90110, Thailand; 2Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, 90110, ThailandCorrespondence: Sasikaan NimmaanratDepartment of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, 90110, ThailandTel +66 88 790 7842Fax +66 74 281656Email snimmaanrat@yahoo.com.auBackground: Cesarean section is the most common major surgery performed globally. Blood group O has been found as a factor affecting pain severity after cesarean section. We aimed to evaluate the predictive factors, including ABO blood group, for the amount of opioid consumption (measured as milligrams of morphine equivalent [MME]) within the first 24 hrs after cesarean section.Methods: This retrospective study was done in 1530 pregnant women who had a cesarean section under the same regimen of spinal anesthesia (2.2 mL of 0.5% hyperbaric bupivacaine and morphine 0.2 mg). All were prescribed regular paracetamol and ibuprofen for postoperative pain control. Univariate and multinomial regression analyses were performed to identify the predictive factors for opioid consumption in the first 24 hrs postoperatively.Results: About 2/5 of them (43.3%) received 0 mg MME, while 25.6%, 23.7% and 7.4% received 1– 5, 6– 10 and > 10 mg MME, respectively. The majority have blood group O (40.6%), while 23.4%, 28% and 8% have blood group A, B and AB, respectively. After univariate and multinomial regression analyses, operation time, opioid consumption in PACU, maximum VNRS within the first 24 hrs and consumption of both paracetamol and ibuprofen were identified as predictive factors for postoperative opioid consumption. ABO blood group exhibited no correlation for opioid requirement postoperatively.Conclusion: ABO blood group is not a predictive factor for opioid requirement within the first 24 hrs following cesarean section. Duration of operation, opioid given in PACU, maximum VNRS on ward and consumption of both paracetamol and ibuprofen have been found to be predictive factors for postcesarean opioid requirement.Keywords: ABO blood group, predictive factors, cesarean section, postoperative opioid consumptionNimmaanrat SThongkumdee WGeater AFOofuvong MBenjhawaleemas PDove Medical Pressarticleabo blood grouppredictive factorscesarean sectionpostoperative opioid consumptionMedicine (General)R5-920ENJournal of Pain Research, Vol Volume 14, Pp 3585-3592 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	abo blood group predictive factors cesarean section postoperative opioid consumption Medicine (General) R5-920
spellingShingle	abo blood group predictive factors cesarean section postoperative opioid consumption Medicine (General) R5-920 Nimmaanrat S Thongkumdee W Geater AF Oofuvong M Benjhawaleemas P Is ABO Blood Group a Predictive Factor for the Amount of Opioid Consumption in the First 24 Hours After Cesarean Section?
description	Sasikaan Nimmaanrat,1 Withaporn Thongkumdee,1 Alan F Geater,2 Maliwan Oofuvong,1 Pannawit Benjhawaleemas1 1Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, 90110, Thailand; 2Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, 90110, ThailandCorrespondence: Sasikaan NimmaanratDepartment of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, 90110, ThailandTel +66 88 790 7842Fax +66 74 281656Email snimmaanrat@yahoo.com.auBackground: Cesarean section is the most common major surgery performed globally. Blood group O has been found as a factor affecting pain severity after cesarean section. We aimed to evaluate the predictive factors, including ABO blood group, for the amount of opioid consumption (measured as milligrams of morphine equivalent [MME]) within the first 24 hrs after cesarean section.Methods: This retrospective study was done in 1530 pregnant women who had a cesarean section under the same regimen of spinal anesthesia (2.2 mL of 0.5% hyperbaric bupivacaine and morphine 0.2 mg). All were prescribed regular paracetamol and ibuprofen for postoperative pain control. Univariate and multinomial regression analyses were performed to identify the predictive factors for opioid consumption in the first 24 hrs postoperatively.Results: About 2/5 of them (43.3%) received 0 mg MME, while 25.6%, 23.7% and 7.4% received 1– 5, 6– 10 and > 10 mg MME, respectively. The majority have blood group O (40.6%), while 23.4%, 28% and 8% have blood group A, B and AB, respectively. After univariate and multinomial regression analyses, operation time, opioid consumption in PACU, maximum VNRS within the first 24 hrs and consumption of both paracetamol and ibuprofen were identified as predictive factors for postoperative opioid consumption. ABO blood group exhibited no correlation for opioid requirement postoperatively.Conclusion: ABO blood group is not a predictive factor for opioid requirement within the first 24 hrs following cesarean section. Duration of operation, opioid given in PACU, maximum VNRS on ward and consumption of both paracetamol and ibuprofen have been found to be predictive factors for postcesarean opioid requirement.Keywords: ABO blood group, predictive factors, cesarean section, postoperative opioid consumption
format	article
author	Nimmaanrat S Thongkumdee W Geater AF Oofuvong M Benjhawaleemas P
author_facet	Nimmaanrat S Thongkumdee W Geater AF Oofuvong M Benjhawaleemas P
author_sort	Nimmaanrat S
title	Is ABO Blood Group a Predictive Factor for the Amount of Opioid Consumption in the First 24 Hours After Cesarean Section?
title_short	Is ABO Blood Group a Predictive Factor for the Amount of Opioid Consumption in the First 24 Hours After Cesarean Section?
title_full	Is ABO Blood Group a Predictive Factor for the Amount of Opioid Consumption in the First 24 Hours After Cesarean Section?
title_fullStr	Is ABO Blood Group a Predictive Factor for the Amount of Opioid Consumption in the First 24 Hours After Cesarean Section?
title_full_unstemmed	Is ABO Blood Group a Predictive Factor for the Amount of Opioid Consumption in the First 24 Hours After Cesarean Section?
title_sort	is abo blood group a predictive factor for the amount of opioid consumption in the first 24 hours after cesarean section?
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/501b4a1f80a54c35983a6a599b120711
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Is ABO Blood Group a Predictive Factor for the Amount of Opioid Consumption in the First 24 Hours After Cesarean Section?

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