The habu genome reveals accelerated evolution of venom protein genes

The habu genome reveals accelerated evolution of venom protein genes

Abstract Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu,...

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Autores principales: Hiroki Shibata, Takahito Chijiwa, Naoko Oda-Ueda, Hitomi Nakamura, Kazuaki Yamaguchi, Shousaku Hattori, Kazumi Matsubara, Yoichi Matsuda, Akifumi Yamashita, Akiko Isomoto, Kazuki Mori, Kosuke Tashiro, Satoru Kuhara, Shinichi Yamasaki, Manabu Fujie, Hiroki Goto, Ryo Koyanagi, Takeshi Takeuchi, Yasuyuki Fukumaki, Motonori Ohno, Eiichi Shoguchi, Kanako Hisata, Noriyuki Satoh, Tomohisa Ogawa
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/501caabb95934dd19843c72b93db0010
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spelling oai:doaj.org-article:501caabb95934dd19843c72b93db00102021-12-02T15:08:55ZThe habu genome reveals accelerated evolution of venom protein genes10.1038/s41598-018-28749-42045-2322https://doaj.org/article/501caabb95934dd19843c72b93db00102018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28749-4https://doaj.org/toc/2045-2322Abstract Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu, Protobothrops flavoviridis. We identified 60 snake venom protein genes (SV) and 224 non-venom paralogs (NV), belonging to 18 gene families. Molecular phylogeny reveals early divergence of SV and NV genes, suggesting that one of the four copies generated through two rounds of whole-genome duplication was modified for use as a toxin. Among them, both SV and NV genes in four major components were extensively duplicated after their diversification, but accelerated evolution is evident exclusively in the SV genes. Both venom-related SV and NV genes are significantly enriched in microchromosomes. The present study thus provides a genetic background for evolution of snake venom composition.Hiroki ShibataTakahito ChijiwaNaoko Oda-UedaHitomi NakamuraKazuaki YamaguchiShousaku HattoriKazumi MatsubaraYoichi MatsudaAkifumi YamashitaAkiko IsomotoKazuki MoriKosuke TashiroSatoru KuharaShinichi YamasakiManabu FujieHiroki GotoRyo KoyanagiTakeshi TakeuchiYasuyuki FukumakiMotonori OhnoEiichi ShoguchiKanako HisataNoriyuki SatohTomohisa OgawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Hiroki Shibata
Takahito Chijiwa
Naoko Oda-Ueda
Hitomi Nakamura
Kazuaki Yamaguchi
Shousaku Hattori
Kazumi Matsubara
Yoichi Matsuda
Akifumi Yamashita
Akiko Isomoto
Kazuki Mori
Kosuke Tashiro
Satoru Kuhara
Shinichi Yamasaki
Manabu Fujie
Hiroki Goto
Ryo Koyanagi
Takeshi Takeuchi
Yasuyuki Fukumaki
Motonori Ohno
Eiichi Shoguchi
Kanako Hisata
Noriyuki Satoh
Tomohisa Ogawa
The habu genome reveals accelerated evolution of venom protein genes
description Abstract Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture. To understand mechanisms involved in snake venom evolution, we decoded here the ~1.4-Gb genome of a habu, Protobothrops flavoviridis. We identified 60 snake venom protein genes (SV) and 224 non-venom paralogs (NV), belonging to 18 gene families. Molecular phylogeny reveals early divergence of SV and NV genes, suggesting that one of the four copies generated through two rounds of whole-genome duplication was modified for use as a toxin. Among them, both SV and NV genes in four major components were extensively duplicated after their diversification, but accelerated evolution is evident exclusively in the SV genes. Both venom-related SV and NV genes are significantly enriched in microchromosomes. The present study thus provides a genetic background for evolution of snake venom composition.
format article
author Hiroki Shibata
Takahito Chijiwa
Naoko Oda-Ueda
Hitomi Nakamura
Kazuaki Yamaguchi
Shousaku Hattori
Kazumi Matsubara
Yoichi Matsuda
Akifumi Yamashita
Akiko Isomoto
Kazuki Mori
Kosuke Tashiro
Satoru Kuhara
Shinichi Yamasaki
Manabu Fujie
Hiroki Goto
Ryo Koyanagi
Takeshi Takeuchi
Yasuyuki Fukumaki
Motonori Ohno
Eiichi Shoguchi
Kanako Hisata
Noriyuki Satoh
Tomohisa Ogawa
author_facet Hiroki Shibata
Takahito Chijiwa
Naoko Oda-Ueda
Hitomi Nakamura
Kazuaki Yamaguchi
Shousaku Hattori
Kazumi Matsubara
Yoichi Matsuda
Akifumi Yamashita
Akiko Isomoto
Kazuki Mori
Kosuke Tashiro
Satoru Kuhara
Shinichi Yamasaki
Manabu Fujie
Hiroki Goto
Ryo Koyanagi
Takeshi Takeuchi
Yasuyuki Fukumaki
Motonori Ohno
Eiichi Shoguchi
Kanako Hisata
Noriyuki Satoh
Tomohisa Ogawa
author_sort Hiroki Shibata
title The habu genome reveals accelerated evolution of venom protein genes
title_short The habu genome reveals accelerated evolution of venom protein genes
title_full The habu genome reveals accelerated evolution of venom protein genes
title_fullStr The habu genome reveals accelerated evolution of venom protein genes
title_full_unstemmed The habu genome reveals accelerated evolution of venom protein genes
title_sort habu genome reveals accelerated evolution of venom protein genes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/501caabb95934dd19843c72b93db0010
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