Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China
Abstract This study aimed to investigate the epidemiological, clinical, and virologic characteristics of avian influenza A (H7N9) confirmed cases from two family clusters in Southeast China. Epidemiological data of the H7N9 confirmed cases and their close contacts were obtained through interviews an...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/50250b338c7249a89408e52eb5edee31 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:50250b338c7249a89408e52eb5edee31 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:50250b338c7249a89408e52eb5edee312021-12-02T12:32:42ZEpidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China10.1038/s41598-017-01761-w2045-2322https://doaj.org/article/50250b338c7249a89408e52eb5edee312017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01761-whttps://doaj.org/toc/2045-2322Abstract This study aimed to investigate the epidemiological, clinical, and virologic characteristics of avian influenza A (H7N9) confirmed cases from two family clusters in Southeast China. Epidemiological data of the H7N9 confirmed cases and their close contacts were obtained through interviews and reviews of medical records. Of the four patients in these two family clusters, two cases had mild symptoms, one had severe symptoms, and one died. Three of the four patients had a history of exposure to live poultry or contaminated environments. The complete genome sequences of the H7N9 viruses from the same family cluster were highly homologous, and the four isolated viruses from the two family clusters exhibited the virologic features of the H7N9 virus, in terms of transmissibility, pathogenicity, host adaptation, and antiviral drug resistance. In addition, our findings indicated that the A/Fujian/18/2015 viral strain contained an additional hemagglutinin G225D substitution, which preferentially binds α2,6-linked sialic acids. The results of this study demonstrate that one family cluster was infected through common exposure to live poultry or contaminated environments, and the other was more likely to be infected through the human-to-human route.Jianfeng XieYuwei WengJianming OuLin ZhaoYanhua ZhangJinzhang WangWei ChenMeng HuangWenqiong XiuHongbin ChenYongjun ZhangBinshan WuWenxiang HeYing ZhuLibin YouZhimiao HuangCanming ZhangLongtao HongWei WangKuicheng ZhengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Jianfeng Xie Yuwei Weng Jianming Ou Lin Zhao Yanhua Zhang Jinzhang Wang Wei Chen Meng Huang Wenqiong Xiu Hongbin Chen Yongjun Zhang Binshan Wu Wenxiang He Ying Zhu Libin You Zhimiao Huang Canming Zhang Longtao Hong Wei Wang Kuicheng Zheng Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China |
| description |
Abstract This study aimed to investigate the epidemiological, clinical, and virologic characteristics of avian influenza A (H7N9) confirmed cases from two family clusters in Southeast China. Epidemiological data of the H7N9 confirmed cases and their close contacts were obtained through interviews and reviews of medical records. Of the four patients in these two family clusters, two cases had mild symptoms, one had severe symptoms, and one died. Three of the four patients had a history of exposure to live poultry or contaminated environments. The complete genome sequences of the H7N9 viruses from the same family cluster were highly homologous, and the four isolated viruses from the two family clusters exhibited the virologic features of the H7N9 virus, in terms of transmissibility, pathogenicity, host adaptation, and antiviral drug resistance. In addition, our findings indicated that the A/Fujian/18/2015 viral strain contained an additional hemagglutinin G225D substitution, which preferentially binds α2,6-linked sialic acids. The results of this study demonstrate that one family cluster was infected through common exposure to live poultry or contaminated environments, and the other was more likely to be infected through the human-to-human route. |
| format |
article |
| author |
Jianfeng Xie Yuwei Weng Jianming Ou Lin Zhao Yanhua Zhang Jinzhang Wang Wei Chen Meng Huang Wenqiong Xiu Hongbin Chen Yongjun Zhang Binshan Wu Wenxiang He Ying Zhu Libin You Zhimiao Huang Canming Zhang Longtao Hong Wei Wang Kuicheng Zheng |
| author_facet |
Jianfeng Xie Yuwei Weng Jianming Ou Lin Zhao Yanhua Zhang Jinzhang Wang Wei Chen Meng Huang Wenqiong Xiu Hongbin Chen Yongjun Zhang Binshan Wu Wenxiang He Ying Zhu Libin You Zhimiao Huang Canming Zhang Longtao Hong Wei Wang Kuicheng Zheng |
| author_sort |
Jianfeng Xie |
| title |
Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China |
| title_short |
Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China |
| title_full |
Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China |
| title_fullStr |
Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China |
| title_full_unstemmed |
Epidemiological, clinical, and virologic features of two family clusters of avian influenza A (H7N9) virus infections in Southeast China |
| title_sort |
epidemiological, clinical, and virologic features of two family clusters of avian influenza a (h7n9) virus infections in southeast china |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/50250b338c7249a89408e52eb5edee31 |
| work_keys_str_mv |
AT jianfengxie epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT yuweiweng epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT jianmingou epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT linzhao epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT yanhuazhang epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT jinzhangwang epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT weichen epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT menghuang epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT wenqiongxiu epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT hongbinchen epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT yongjunzhang epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT binshanwu epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT wenxianghe epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT yingzhu epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT libinyou epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT zhimiaohuang epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT canmingzhang epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT longtaohong epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT weiwang epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina AT kuichengzheng epidemiologicalclinicalandvirologicfeaturesoftwofamilyclustersofavianinfluenzaah7n9virusinfectionsinsoutheastchina |
| _version_ |
1718393977178161152 |