Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT
Michael Hettchen,1 Simon von Stengel,1 Matthias Kohl,2 Marie H Murphy,3 Mahdieh Shojaa,1 Mansour Ghasemikaram,1 Laura Bragonzoni,4 Francesco Benvenuti,4 Claudio Ripamonti,5 Maria Grazia Benedetti,6 Mikko Julin,7 Tapani Risto,7 Wolfgang Kemmler1 1Institute of Medical Physics, Friedrich-Alexander Univ...
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Dove Medical Press
2021
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multipurpose exercise bone mineral density early post-menopause Geriatrics RC952-954.6 |
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multipurpose exercise bone mineral density early post-menopause Geriatrics RC952-954.6 Hettchen M von Stengel S Kohl M Murphy MH Shojaa M Ghasemikaram M Bragonzoni L Benvenuti F Ripamonti C Benedetti MG Julin M Risto T Kemmler W Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT |
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Michael Hettchen,1 Simon von Stengel,1 Matthias Kohl,2 Marie H Murphy,3 Mahdieh Shojaa,1 Mansour Ghasemikaram,1 Laura Bragonzoni,4 Francesco Benvenuti,4 Claudio Ripamonti,5 Maria Grazia Benedetti,6 Mikko Julin,7 Tapani Risto,7 Wolfgang Kemmler1 1Institute of Medical Physics, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany; 2Department of Medical and Life Sciences, University of Furtwangen, Schwenningen, Germany; 3Doctoral College, Ulster University, Newtownabbey, Antrim, Northern Ireland, UK; 4University of Bologna, Campus Rimini, Rimini, Italy; 5Center for Osteoporosis and Bone Metabolic Disease, Rizzoli Orthopaedic Institute, Bologna, Italy; 6Physical Medicine and Rehabilitation Unit, IRCCS - Rizzoli Orthopaedic Institute, Bologna, Italy; 7Laurea University of Applied Sciences, Espoo, FinlandCorrespondence: Michael HettchenInstitute of Medical Physics, Friedrich-Alexander-University Erlangen-Nürnberg, Henkestrasse 91, Erlangen 91052, GermanyTel +49 9131-8525883Fax +49 9131-8522824Email michael.hettchen@imp.uni-erlangen.deAbstract: The menopausal transition is a critical period in women’s lives. Exercise might be the most promising non-pharmaceutic intervention to address the large variety of risk factors related to the pronounced estradiol decline during peri- and early-postmenopause. The aim of this study was to determine the effect of an 18-month multipurpose exercise program on risk factors and symptoms related to the menopausal transition. Fifty-four women 1– 5 years postmenopause with osteopenia or osteoporosis were randomly assigned 1) to a high impact weight-bearing/high-intensity/velocity resistance training group (EG: n=27) exercising three times a week or 2) to an attendance control group (CG: n=27) that performed low-intensity exercise once a week. Both groups were supplemented with cholecalciferol and calcium. The primary study endpoint was bone mineral density (BMD) at lumbar spine (LS) and total hip, secondary outcomes were lean body mass (LBM), total and abdominal body percentage, metabolic syndrome Z-Score (MetS-Z), menopausal symptoms and muscle strength and power. Due to COVID-19, the study was stopped after 13 months. We observed significant effects for BMD-LS (EG: 0.002± .018 versus CG: − .009± 0.018 mg/cm2, p=0.027) but not for BMD total hip (EG: − 0.01± .016 versus CG: − .009± 0.020 mg/cm2, p=0.129). LBM improved significantly in the EG and decreased in the CG (0.39± 1.08 vs − 0.37± 1.34 kg, p=0.026). Total and abdominal body fat improved significantly in the EG and was maintained in the CG (− 1.44± 1.49 vs − 0.02± 1.55 kg, p=0.002 and -1.50± 2.33 vs 0.08± 2.07 kg, p=0.011). Significant effects in favor of the EG were also determined for menopausal symptoms (p=0.029), hip/leg extension strength (p< 0.001) and power (p< 0.001). However, changes of the MetS-Z did not differ significantly (p=0.149) between EG and CG. In summary, with minor exceptions, we demonstrated the effectiveness of a multipurpose exercise protocol dedicated to early-postmenopausal women on various risk factors and complaints related to the menopausal transition.Keywords: multipurpose exercise, bone mineral density, early postmenopause |
| format |
article |
| author |
Hettchen M von Stengel S Kohl M Murphy MH Shojaa M Ghasemikaram M Bragonzoni L Benvenuti F Ripamonti C Benedetti MG Julin M Risto T Kemmler W |
| author_facet |
Hettchen M von Stengel S Kohl M Murphy MH Shojaa M Ghasemikaram M Bragonzoni L Benvenuti F Ripamonti C Benedetti MG Julin M Risto T Kemmler W |
| author_sort |
Hettchen M |
| title |
Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT |
| title_short |
Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT |
| title_full |
Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT |
| title_fullStr |
Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT |
| title_full_unstemmed |
Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT |
| title_sort |
changes in menopausal risk factors in early postmenopausal osteopenic women after 13 months of high-intensity exercise: the randomized controlled actlife-rct |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/50250f86bae241edb900f0c8e2f6c74a |
| work_keys_str_mv |
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oai:doaj.org-article:50250f86bae241edb900f0c8e2f6c74a2021-12-02T15:14:37ZChanges in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT1178-1998https://doaj.org/article/50250f86bae241edb900f0c8e2f6c74a2021-01-01T00:00:00Zhttps://www.dovepress.com/changes-in-menopausal-risk-factors-in-early-postmenopausal-osteopenic--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Michael Hettchen,1 Simon von Stengel,1 Matthias Kohl,2 Marie H Murphy,3 Mahdieh Shojaa,1 Mansour Ghasemikaram,1 Laura Bragonzoni,4 Francesco Benvenuti,4 Claudio Ripamonti,5 Maria Grazia Benedetti,6 Mikko Julin,7 Tapani Risto,7 Wolfgang Kemmler1 1Institute of Medical Physics, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany; 2Department of Medical and Life Sciences, University of Furtwangen, Schwenningen, Germany; 3Doctoral College, Ulster University, Newtownabbey, Antrim, Northern Ireland, UK; 4University of Bologna, Campus Rimini, Rimini, Italy; 5Center for Osteoporosis and Bone Metabolic Disease, Rizzoli Orthopaedic Institute, Bologna, Italy; 6Physical Medicine and Rehabilitation Unit, IRCCS - Rizzoli Orthopaedic Institute, Bologna, Italy; 7Laurea University of Applied Sciences, Espoo, FinlandCorrespondence: Michael HettchenInstitute of Medical Physics, Friedrich-Alexander-University Erlangen-Nürnberg, Henkestrasse 91, Erlangen 91052, GermanyTel +49 9131-8525883Fax +49 9131-8522824Email michael.hettchen@imp.uni-erlangen.deAbstract: The menopausal transition is a critical period in women’s lives. Exercise might be the most promising non-pharmaceutic intervention to address the large variety of risk factors related to the pronounced estradiol decline during peri- and early-postmenopause. The aim of this study was to determine the effect of an 18-month multipurpose exercise program on risk factors and symptoms related to the menopausal transition. Fifty-four women 1– 5 years postmenopause with osteopenia or osteoporosis were randomly assigned 1) to a high impact weight-bearing/high-intensity/velocity resistance training group (EG: n=27) exercising three times a week or 2) to an attendance control group (CG: n=27) that performed low-intensity exercise once a week. Both groups were supplemented with cholecalciferol and calcium. The primary study endpoint was bone mineral density (BMD) at lumbar spine (LS) and total hip, secondary outcomes were lean body mass (LBM), total and abdominal body percentage, metabolic syndrome Z-Score (MetS-Z), menopausal symptoms and muscle strength and power. Due to COVID-19, the study was stopped after 13 months. We observed significant effects for BMD-LS (EG: 0.002± .018 versus CG: − .009± 0.018 mg/cm2, p=0.027) but not for BMD total hip (EG: − 0.01± .016 versus CG: − .009± 0.020 mg/cm2, p=0.129). LBM improved significantly in the EG and decreased in the CG (0.39± 1.08 vs − 0.37± 1.34 kg, p=0.026). Total and abdominal body fat improved significantly in the EG and was maintained in the CG (− 1.44± 1.49 vs − 0.02± 1.55 kg, p=0.002 and -1.50± 2.33 vs 0.08± 2.07 kg, p=0.011). Significant effects in favor of the EG were also determined for menopausal symptoms (p=0.029), hip/leg extension strength (p< 0.001) and power (p< 0.001). However, changes of the MetS-Z did not differ significantly (p=0.149) between EG and CG. In summary, with minor exceptions, we demonstrated the effectiveness of a multipurpose exercise protocol dedicated to early-postmenopausal women on various risk factors and complaints related to the menopausal transition.Keywords: multipurpose exercise, bone mineral density, early postmenopauseHettchen Mvon Stengel SKohl MMurphy MHShojaa MGhasemikaram MBragonzoni LBenvenuti FRipamonti CBenedetti MGJulin MRisto TKemmler WDove Medical Pressarticlemultipurpose exercisebone mineral densityearly post-menopauseGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 83-96 (2021) |