Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion

Effective delivery of signals from the cell surface to the nucleus is a key to activate gene transcription. Here, the authors show how endosomes containing EphA2 are transported and captured at the nuclear surface, triggering depletion of G-actin from the nucleus and activating MRTF signalling.

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Autores principales:	Sergi Marco, Matthew Neilson, Madeleine Moore, Arantxa Perez-Garcia, Holly Hall, Louise Mitchell, Sergio Lilla, Giovani R. Blanco, Ann Hedley, Sara Zanivan, Jim C. Norman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5026a0dde67b478d8be77b8ddb4c8629
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spelling	oai:doaj.org-article:5026a0dde67b478d8be77b8ddb4c86292021-11-28T12:31:43ZNuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion10.1038/s41467-021-26839-y2041-1723https://doaj.org/article/5026a0dde67b478d8be77b8ddb4c86292021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26839-yhttps://doaj.org/toc/2041-1723Effective delivery of signals from the cell surface to the nucleus is a key to activate gene transcription. Here, the authors show how endosomes containing EphA2 are transported and captured at the nuclear surface, triggering depletion of G-actin from the nucleus and activating MRTF signalling.Sergi MarcoMatthew NeilsonMadeleine MooreArantxa Perez-GarciaHolly HallLouise MitchellSergio LillaGiovani R. BlancoAnn HedleySara ZanivanJim C. NormanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sergi Marco Matthew Neilson Madeleine Moore Arantxa Perez-Garcia Holly Hall Louise Mitchell Sergio Lilla Giovani R. Blanco Ann Hedley Sara Zanivan Jim C. Norman Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
description	Effective delivery of signals from the cell surface to the nucleus is a key to activate gene transcription. Here, the authors show how endosomes containing EphA2 are transported and captured at the nuclear surface, triggering depletion of G-actin from the nucleus and activating MRTF signalling.
format	article
author	Sergi Marco Matthew Neilson Madeleine Moore Arantxa Perez-Garcia Holly Hall Louise Mitchell Sergio Lilla Giovani R. Blanco Ann Hedley Sara Zanivan Jim C. Norman
author_facet	Sergi Marco Matthew Neilson Madeleine Moore Arantxa Perez-Garcia Holly Hall Louise Mitchell Sergio Lilla Giovani R. Blanco Ann Hedley Sara Zanivan Jim C. Norman
author_sort	Sergi Marco
title	Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
title_short	Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
title_full	Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
title_fullStr	Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
title_full_unstemmed	Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
title_sort	nuclear-capture of endosomes depletes nuclear g-actin to promote srf/mrtf activation and cancer cell invasion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5026a0dde67b478d8be77b8ddb4c8629
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Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion

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