Reader domain specificity and lysine demethylase-4 family function

Reader domain specificity and lysine demethylase-4 family function

KDM4 histone demethylases target specific chromatin regions by a mechanism that is not fully characterised. Here, the authors identify trimethyl-lysine histone-binding preferences for closely related KDM4 double tudor domains and use structural and biochemical information to examine the molecular de...

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Autores principales: Zhangli Su, Fengbin Wang, Jin-Hee Lee, Kimberly E. Stephens, Romeo Papazyan, Ekaterina Voronina, Kimberly A. Krautkramer, Ana Raman, Jeremy J. Thorpe, Melissa D. Boersma, Vyacheslav I. Kuznetsov, Mitchell D. Miller, Sean D. Taverna, George N. Phillips, John M. Denu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/502865cd91ae47c58370ec2f6dd3787b
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Sumario:KDM4 histone demethylases target specific chromatin regions by a mechanism that is not fully characterised. Here, the authors identify trimethyl-lysine histone-binding preferences for closely related KDM4 double tudor domains and use structural and biochemical information to examine the molecular details of this interaction.

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