Ten‐year course of treated bipolar I disorder: The role of polarity at onset

Abstract Introduction Early‐stage predictors of illness course are needed in bipolar disorder (BD). Differences among patients with a first depressive versus maniac/hypomanic episode have been stated, although in most studies, memory bias and time from onset to start of specialized treatment might i...

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Autores principales:	María Yoldi‐Negrete, Ana Fresán‐Orellana, Mariana Jiménez‐Tirado, Sara Martínez‐Camarillo, Lino Palacios‐Cruz, Eduard Vieta, Hiram Ortega‐Ortiz, Claudia Becerra‐Palars, Doris Gutiérrez‐Mora, Beatriz Camarena Medellín
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	psychiatric disorders psychiatry psychosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/502c3db499d64c1590d7a09a924b6df7
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spelling	oai:doaj.org-article:502c3db499d64c1590d7a09a924b6df72021-11-25T06:06:36ZTen‐year course of treated bipolar I disorder: The role of polarity at onset2162-327910.1002/brb3.2279https://doaj.org/article/502c3db499d64c1590d7a09a924b6df72021-11-01T00:00:00Zhttps://doi.org/10.1002/brb3.2279https://doaj.org/toc/2162-3279Abstract Introduction Early‐stage predictors of illness course are needed in bipolar disorder (BD). Differences among patients with a first depressive versus maniac/hypomanic episode have been stated, although in most studies, memory bias and time from onset to start of specialized treatment might interfere. The aim was to compare the first 10 years of illness course according to polarity at onset. Methods 49 type I BD patients admitted for treatment for a first‐time affective episode and a following 10‐year attendance to the institution were included. A retrospective year by year comparison according to polarity at onset (depressive (DPO) or maniac (MPO)) was performed. Cramer's V and Cohen d were computed to determine effect size. Results 59.2% (n = 29) started with MPO. Both groups were similar in demographic and social outcome characteristics, clinical features, and treatment variables. Patients with DPO reported more depressive episodes than MPO patients (U = 149.0 p < .001, Cohen's d = 0.87); both groups had a similar number of manic episodes. Only during the first year of follow‐up, suicide attempts (SA) were more frequent in patients with DPO while the presence of a psychotic episode and psychiatric hospitalizations were more frequent in the MPO group. Conclusion According to these findings, it can be concluded that illness onset is only indicative of depressive predominant polarity but is not related to other poor prognostic variables after the first year of illness onset, in treated BD. SA in the first year of an affective disorder could represent a marker of BD.María Yoldi‐NegreteAna Fresán‐OrellanaMariana Jiménez‐TiradoSara Martínez‐CamarilloLino Palacios‐CruzEduard VietaHiram Ortega‐OrtizClaudia Becerra‐PalarsDoris Gutiérrez‐MoraBeatriz Camarena MedellínWileyarticlepsychiatric disorderspsychiatrypsychosisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain and Behavior, Vol 11, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psychiatric disorders psychiatry psychosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	psychiatric disorders psychiatry psychosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 María Yoldi‐Negrete Ana Fresán‐Orellana Mariana Jiménez‐Tirado Sara Martínez‐Camarillo Lino Palacios‐Cruz Eduard Vieta Hiram Ortega‐Ortiz Claudia Becerra‐Palars Doris Gutiérrez‐Mora Beatriz Camarena Medellín Ten‐year course of treated bipolar I disorder: The role of polarity at onset
description	Abstract Introduction Early‐stage predictors of illness course are needed in bipolar disorder (BD). Differences among patients with a first depressive versus maniac/hypomanic episode have been stated, although in most studies, memory bias and time from onset to start of specialized treatment might interfere. The aim was to compare the first 10 years of illness course according to polarity at onset. Methods 49 type I BD patients admitted for treatment for a first‐time affective episode and a following 10‐year attendance to the institution were included. A retrospective year by year comparison according to polarity at onset (depressive (DPO) or maniac (MPO)) was performed. Cramer's V and Cohen d were computed to determine effect size. Results 59.2% (n = 29) started with MPO. Both groups were similar in demographic and social outcome characteristics, clinical features, and treatment variables. Patients with DPO reported more depressive episodes than MPO patients (U = 149.0 p < .001, Cohen's d = 0.87); both groups had a similar number of manic episodes. Only during the first year of follow‐up, suicide attempts (SA) were more frequent in patients with DPO while the presence of a psychotic episode and psychiatric hospitalizations were more frequent in the MPO group. Conclusion According to these findings, it can be concluded that illness onset is only indicative of depressive predominant polarity but is not related to other poor prognostic variables after the first year of illness onset, in treated BD. SA in the first year of an affective disorder could represent a marker of BD.
format	article
author	María Yoldi‐Negrete Ana Fresán‐Orellana Mariana Jiménez‐Tirado Sara Martínez‐Camarillo Lino Palacios‐Cruz Eduard Vieta Hiram Ortega‐Ortiz Claudia Becerra‐Palars Doris Gutiérrez‐Mora Beatriz Camarena Medellín
author_facet	María Yoldi‐Negrete Ana Fresán‐Orellana Mariana Jiménez‐Tirado Sara Martínez‐Camarillo Lino Palacios‐Cruz Eduard Vieta Hiram Ortega‐Ortiz Claudia Becerra‐Palars Doris Gutiérrez‐Mora Beatriz Camarena Medellín
author_sort	María Yoldi‐Negrete
title	Ten‐year course of treated bipolar I disorder: The role of polarity at onset
title_short	Ten‐year course of treated bipolar I disorder: The role of polarity at onset
title_full	Ten‐year course of treated bipolar I disorder: The role of polarity at onset
title_fullStr	Ten‐year course of treated bipolar I disorder: The role of polarity at onset
title_full_unstemmed	Ten‐year course of treated bipolar I disorder: The role of polarity at onset
title_sort	ten‐year course of treated bipolar i disorder: the role of polarity at onset
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/502c3db499d64c1590d7a09a924b6df7
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Ten‐year course of treated bipolar I disorder: The role of polarity at onset

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