Treatment of obese patients with binge eating disorder using topiramate: a review

Paolo Leombruni, Luca Lavagnino, Secondo FassinoDepartment of Neurosciences, Psychiatry Section, University of Torino, Centre for Eating Disorders and Obesity, Torino, ItalyAbstract: Topiramate is an anticonvulsant drug used for the treatment of epilepsy and prophylaxis of migraine. Some authors hav...

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Autores principales:	Paolo Leombruni, Luca Lavagnino, Secondo Fassino
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/502f4828784c4aa684031723bd052e3f
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spelling	oai:doaj.org-article:502f4828784c4aa684031723bd052e3f2021-12-02T00:40:44ZTreatment of obese patients with binge eating disorder using topiramate: a review1176-63281178-2021https://doaj.org/article/502f4828784c4aa684031723bd052e3f2009-07-01T00:00:00Zhttp://www.dovepress.com/treatment-of-obese-patients-with-binge-eating-disorder-using-topiramat-a3339https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Paolo Leombruni, Luca Lavagnino, Secondo FassinoDepartment of Neurosciences, Psychiatry Section, University of Torino, Centre for Eating Disorders and Obesity, Torino, ItalyAbstract: Topiramate is an anticonvulsant drug used for the treatment of epilepsy and prophylaxis of migraine. Some authors have proposed its use as a mood stabilizer and have reported its efficacy in reducing impulsiveness and improving mood regulation, possibly via its antagonism to glutamatergic transmission in the lateral hypothalamus, although this indication is still controversial. Weight loss is a side effect consistently reported in the medical literature in patients treated with topiramate. Given its potential role in stabilizing mood and reducing impulse control problems and weight, topiramate has been proposed as a treatment for obese patients with binge eating disorder (BED). The aim of this paper is to review published data on the efficacy and safety of topiramate for the treatment of obese subjects with BED. Although the evidence is preliminary, topiramate appears to be a relatively safe and effective treatment for obese subjects with BED. Limitations of the studies and future directions for research are discussed.Keywords: topiramate, binge eating disorder, obesity Paolo LeombruniLuca LavagninoSecondo FassinoDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 385-392 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Paolo Leombruni Luca Lavagnino Secondo Fassino Treatment of obese patients with binge eating disorder using topiramate: a review
description	Paolo Leombruni, Luca Lavagnino, Secondo FassinoDepartment of Neurosciences, Psychiatry Section, University of Torino, Centre for Eating Disorders and Obesity, Torino, ItalyAbstract: Topiramate is an anticonvulsant drug used for the treatment of epilepsy and prophylaxis of migraine. Some authors have proposed its use as a mood stabilizer and have reported its efficacy in reducing impulsiveness and improving mood regulation, possibly via its antagonism to glutamatergic transmission in the lateral hypothalamus, although this indication is still controversial. Weight loss is a side effect consistently reported in the medical literature in patients treated with topiramate. Given its potential role in stabilizing mood and reducing impulse control problems and weight, topiramate has been proposed as a treatment for obese patients with binge eating disorder (BED). The aim of this paper is to review published data on the efficacy and safety of topiramate for the treatment of obese subjects with BED. Although the evidence is preliminary, topiramate appears to be a relatively safe and effective treatment for obese subjects with BED. Limitations of the studies and future directions for research are discussed.Keywords: topiramate, binge eating disorder, obesity
format	article
author	Paolo Leombruni Luca Lavagnino Secondo Fassino
author_facet	Paolo Leombruni Luca Lavagnino Secondo Fassino
author_sort	Paolo Leombruni
title	Treatment of obese patients with binge eating disorder using topiramate: a review
title_short	Treatment of obese patients with binge eating disorder using topiramate: a review
title_full	Treatment of obese patients with binge eating disorder using topiramate: a review
title_fullStr	Treatment of obese patients with binge eating disorder using topiramate: a review
title_full_unstemmed	Treatment of obese patients with binge eating disorder using topiramate: a review
title_sort	treatment of obese patients with binge eating disorder using topiramate: a review
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/502f4828784c4aa684031723bd052e3f
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Treatment of obese patients with binge eating disorder using topiramate: a review

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