IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke.

Chronic Obstructive Pulmonary Disease (COPD) is characterized by airspace enlargement and peribronchial lymphoid follicles; however, the immunological mechanisms leading to these pathologic changes remain undefined. Here we show that cigarette smoke is a selective adjuvant that augments in vitro and...

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Autores principales: Kong Chen, Derek A Pociask, Jeremy P McAleer, Yvonne R Chan, John F Alcorn, James L Kreindler, Matthew R Keyser, Steven D Shapiro, A McGarry Houghton, Jay K Kolls, Mingquan Zheng
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/50301d1cf40c4f6384de173cb992c82e
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