Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues

Mucosal immunisation is important for initiating mucosal CD8+ Tcell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for ILC1 recruiting CD8+ T cells to the mucosa after s...

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Autores principales:	Marija Zaric, Pablo D. Becker, Catherine Hervouet, Petya Kalcheva, Andor Doszpoly, Negin Blattman, Lauren A. O’ Neill, Barbara Ibarzo Yus, Clement Cocita, Sung-Yun Kwon, Andrew H. Baker, Graham M. Lord, Linda S. Klavinskis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50310e1b618c4e9db13be9368bb83233
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spelling	oai:doaj.org-article:50310e1b618c4e9db13be9368bb832332021-12-02T16:50:57ZSkin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues10.1038/s41467-019-09969-22041-1723https://doaj.org/article/50310e1b618c4e9db13be9368bb832332019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09969-2https://doaj.org/toc/2041-1723Mucosal immunisation is important for initiating mucosal CD8+ Tcell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for ILC1 recruiting CD8+ T cells to the mucosa after skin immunisation.Marija ZaricPablo D. BeckerCatherine HervouetPetya KalchevaAndor DoszpolyNegin BlattmanLauren A. O’ NeillBarbara Ibarzo YusClement CocitaSung-Yun KwonAndrew H. BakerGraham M. LordLinda S. KlavinskisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marija Zaric Pablo D. Becker Catherine Hervouet Petya Kalcheva Andor Doszpoly Negin Blattman Lauren A. O’ Neill Barbara Ibarzo Yus Clement Cocita Sung-Yun Kwon Andrew H. Baker Graham M. Lord Linda S. Klavinskis Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues
description	Mucosal immunisation is important for initiating mucosal CD8+ Tcell responses but mucosal recruitment of protective CD8+ T cells can also be induced by skin immunisation. Here the authors examine the underlying mechanism and report a novel role for ILC1 recruiting CD8+ T cells to the mucosa after skin immunisation.
format	article
author	Marija Zaric Pablo D. Becker Catherine Hervouet Petya Kalcheva Andor Doszpoly Negin Blattman Lauren A. O’ Neill Barbara Ibarzo Yus Clement Cocita Sung-Yun Kwon Andrew H. Baker Graham M. Lord Linda S. Klavinskis
author_facet	Marija Zaric Pablo D. Becker Catherine Hervouet Petya Kalcheva Andor Doszpoly Negin Blattman Lauren A. O’ Neill Barbara Ibarzo Yus Clement Cocita Sung-Yun Kwon Andrew H. Baker Graham M. Lord Linda S. Klavinskis
author_sort	Marija Zaric
title	Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues
title_short	Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues
title_full	Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues
title_fullStr	Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues
title_full_unstemmed	Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues
title_sort	skin immunisation activates an innate lymphoid cell-monocyte axis regulating cd8+ effector recruitment to mucosal tissues
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/50310e1b618c4e9db13be9368bb83233
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Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues

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