Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions

In order to investigate the possible role of Epstein–Barr virus (EBV) in systemic lupus erythematosus (SLE) and its associated oral lesions, a pilot case–control study was performed. A total of 31 patients (18 females and 13 males) were enrolled in the study and divided into two groups: group A incl...

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Autores principales:	Alessio Buonavoglia, Patrizia Leone, Marcella Prete, Antonio Giovanni Solimando, Chiara Guastadisegno, Gianvito Lanave, Michele Camero, Vito Martella, Lorenzo Lo Muzio, Vito Racanelli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	systemic lupus erythematosus Epstein–Barr virus oral lesions Medicine R
Acceso en línea:	https://doaj.org/article/5033016b04b64b069969945310a7da27
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spelling	oai:doaj.org-article:5033016b04b64b069969945310a7da272021-11-11T17:37:26ZEpstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions10.3390/jcm102149952077-0383https://doaj.org/article/5033016b04b64b069969945310a7da272021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4995https://doaj.org/toc/2077-0383In order to investigate the possible role of Epstein–Barr virus (EBV) in systemic lupus erythematosus (SLE) and its associated oral lesions, a pilot case–control study was performed. A total of 31 patients (18 females and 13 males) were enrolled in the study and divided into two groups: group A included 16 patients with diagnosis of SLE and group B included 15 healthy individuals. Salivary swab samples were collected and subjected to molecular screening by real-time quantitative PCR (qPCR) for the detection of EBV DNA. EBV DNA was significantly detected in 8/16 (50%) SLE patients and in 5/7 (71.4%) subjects with SLE-associated oral lesions. Since EBV is one of the most common viruses in the human population, it is difficult to understand if it is the causative agent of SLE or, vice versa, if SLE is able to trigger the reactivation of EBV. This study highlights a significant association between the presence of EBV and both SLE and SLE-related oral lesions and provides rationale for further investigation into the role of EBV in SLE pathogenesis.Alessio BuonavogliaPatrizia LeoneMarcella PreteAntonio Giovanni SolimandoChiara GuastadisegnoGianvito LanaveMichele CameroVito MartellaLorenzo Lo MuzioVito RacanelliMDPI AGarticlesystemic lupus erythematosusEpstein–Barr virusoral lesionsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4995, p 4995 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic lupus erythematosus Epstein–Barr virus oral lesions Medicine R
spellingShingle	systemic lupus erythematosus Epstein–Barr virus oral lesions Medicine R Alessio Buonavoglia Patrizia Leone Marcella Prete Antonio Giovanni Solimando Chiara Guastadisegno Gianvito Lanave Michele Camero Vito Martella Lorenzo Lo Muzio Vito Racanelli Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions
description	In order to investigate the possible role of Epstein–Barr virus (EBV) in systemic lupus erythematosus (SLE) and its associated oral lesions, a pilot case–control study was performed. A total of 31 patients (18 females and 13 males) were enrolled in the study and divided into two groups: group A included 16 patients with diagnosis of SLE and group B included 15 healthy individuals. Salivary swab samples were collected and subjected to molecular screening by real-time quantitative PCR (qPCR) for the detection of EBV DNA. EBV DNA was significantly detected in 8/16 (50%) SLE patients and in 5/7 (71.4%) subjects with SLE-associated oral lesions. Since EBV is one of the most common viruses in the human population, it is difficult to understand if it is the causative agent of SLE or, vice versa, if SLE is able to trigger the reactivation of EBV. This study highlights a significant association between the presence of EBV and both SLE and SLE-related oral lesions and provides rationale for further investigation into the role of EBV in SLE pathogenesis.
format	article
author	Alessio Buonavoglia Patrizia Leone Marcella Prete Antonio Giovanni Solimando Chiara Guastadisegno Gianvito Lanave Michele Camero Vito Martella Lorenzo Lo Muzio Vito Racanelli
author_facet	Alessio Buonavoglia Patrizia Leone Marcella Prete Antonio Giovanni Solimando Chiara Guastadisegno Gianvito Lanave Michele Camero Vito Martella Lorenzo Lo Muzio Vito Racanelli
author_sort	Alessio Buonavoglia
title	Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions
title_short	Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions
title_full	Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions
title_fullStr	Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions
title_full_unstemmed	Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions
title_sort	epstein–barr virus in salivary samples from systemic lupus erythematosus patients with oral lesions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5033016b04b64b069969945310a7da27
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Epstein–Barr Virus in Salivary Samples from Systemic Lupus Erythematosus Patients with Oral Lesions

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