Oxidative / Nitrosative Stress ss in Chronic Heart Failure: A Critical Review

Heart failure constitutes a major cardiovascular health hazard worldwide. It afflicts over 1% of the general population and nearly 1 in 10 of the elderly. Chronic heart failure (CHF) also accounts for an increasing proportion of available hospital resources. Moreover, despite intense medical care, t...

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Autores principales:	Doğan Yücel, Mehmet t Şeneş, B. Ç . Çiğdem T m Topkaya ya, Oğuzhan Zengi
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2006
Materias:	Dextransucrase dextran polysaccharide Leuconostoc Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/503980c59f0c4c239bdecf4064b321c9
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spelling	oai:doaj.org-article:503980c59f0c4c239bdecf4064b321c92021-12-02T11:27:03ZOxidative / Nitrosative Stress ss in Chronic Heart Failure: A Critical Review0250-46851303-829Xhttps://doaj.org/article/503980c59f0c4c239bdecf4064b321c92006-06-01T00:00:00Zhttp://www.turkjbiochem.com/2006/086_095.pdfhttps://doaj.org/toc/0250-4685https://doaj.org/toc/1303-829XHeart failure constitutes a major cardiovascular health hazard worldwide. It afflicts over 1% of the general population and nearly 1 in 10 of the elderly. Chronic heart failure (CHF) also accounts for an increasing proportion of available hospital resources. Moreover, despite intense medical care, the outlook ok for the patient with chronic heart failure continues to remain quite dismal; both quality of life and survival prospects are severely limited. Ventricular arrhythmias, thromboembolic phenomena and sudden death are common in patients with this syndrome. There is extensive experimental evidence from in vitro and animal experimentsthat chronic heart failu lure is a state of increased oxidative and nitrosative stress. Moreover, in animal models, the development of CHF is accompanied by changes in the antioxidant defense mechanisms of the myocardium as well as evidence of oxidative myocardial inju jury. On the other hand, in general, increased nitrosativestress is linked to increased oxidative stress. Alterations in nitric oxide synthase NOS) activity and nitric oxide (•NO) may contribute to failing heart. These data have led to the hypothesis that increased oxidative and nitrosative stress at least maybe a mechanism of disease progression in CHF. In this article, studies on oxidative/nitrosative stress in CHF are reviewed with all dimensions.Doğan YücelMehmet t Şeneş,B. Ç . Çiğdem T m Topkaya ya,Oğuzhan ZengiDe GruyterarticleDextransucrasedextranpolysaccharideLeuconostocBiochemistryQD415-436ENTürk Biyokimya Dergisi, Vol 31, Iss 2, Pp 86-95 (2006)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dextransucrase dextran polysaccharide Leuconostoc Biochemistry QD415-436
spellingShingle	Dextransucrase dextran polysaccharide Leuconostoc Biochemistry QD415-436 Doğan Yücel Mehmet t Şeneş, B. Ç . Çiğdem T m Topkaya ya, Oğuzhan Zengi Oxidative / Nitrosative Stress ss in Chronic Heart Failure: A Critical Review
description	Heart failure constitutes a major cardiovascular health hazard worldwide. It afflicts over 1% of the general population and nearly 1 in 10 of the elderly. Chronic heart failure (CHF) also accounts for an increasing proportion of available hospital resources. Moreover, despite intense medical care, the outlook ok for the patient with chronic heart failure continues to remain quite dismal; both quality of life and survival prospects are severely limited. Ventricular arrhythmias, thromboembolic phenomena and sudden death are common in patients with this syndrome. There is extensive experimental evidence from in vitro and animal experimentsthat chronic heart failu lure is a state of increased oxidative and nitrosative stress. Moreover, in animal models, the development of CHF is accompanied by changes in the antioxidant defense mechanisms of the myocardium as well as evidence of oxidative myocardial inju jury. On the other hand, in general, increased nitrosativestress is linked to increased oxidative stress. Alterations in nitric oxide synthase NOS) activity and nitric oxide (•NO) may contribute to failing heart. These data have led to the hypothesis that increased oxidative and nitrosative stress at least maybe a mechanism of disease progression in CHF. In this article, studies on oxidative/nitrosative stress in CHF are reviewed with all dimensions.
format	article
author	Doğan Yücel Mehmet t Şeneş, B. Ç . Çiğdem T m Topkaya ya, Oğuzhan Zengi
author_facet	Doğan Yücel Mehmet t Şeneş, B. Ç . Çiğdem T m Topkaya ya, Oğuzhan Zengi
author_sort	Doğan Yücel
title	Oxidative / Nitrosative Stress ss in Chronic Heart Failure: A Critical Review
title_short	Oxidative / Nitrosative Stress ss in Chronic Heart Failure: A Critical Review
title_full	Oxidative / Nitrosative Stress ss in Chronic Heart Failure: A Critical Review
title_fullStr	Oxidative / Nitrosative Stress ss in Chronic Heart Failure: A Critical Review
title_full_unstemmed	Oxidative / Nitrosative Stress ss in Chronic Heart Failure: A Critical Review
title_sort	oxidative / nitrosative stress ss in chronic heart failure: a critical review
publisher	De Gruyter
publishDate	2006
url	https://doaj.org/article/503980c59f0c4c239bdecf4064b321c9
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Oxidative / Nitrosative Stress ss in Chronic Heart Failure: A Critical Review

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