Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

Triple negative breast cancers harbor multiple copy number aberrations driving gene expression changes thought to underpin their malignant phenotypes. Here the authors integrate these features, finding and functionally validating 37 gene addictions among which they identify the mechanism of addictio...

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Autores principales:	Nirmesh Patel, Daniel Weekes, Konstantinos Drosopoulos, Patrycja Gazinska, Elodie Noel, Mamun Rashid, Hasan Mirza, Jelmar Quist, Fara Brasó-Maristany, Sumi Mathew, Riccardo Ferro, Ana Mendes Pereira, Cynthia Prince, Farzana Noor, Erika Francesch-Domenech, Rebecca Marlow, Emanuele de Rinaldis, Anita Grigoriadis, Spiros Linardopoulos, Pierfrancesco Marra, Andrew N. J. Tutt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5040e6ddb1d140d09e37fbc06a8ca400
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spelling	oai:doaj.org-article:5040e6ddb1d140d09e37fbc06a8ca4002021-12-02T17:32:44ZIntegrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer10.1038/s41467-018-03283-z2041-1723https://doaj.org/article/5040e6ddb1d140d09e37fbc06a8ca4002018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03283-zhttps://doaj.org/toc/2041-1723Triple negative breast cancers harbor multiple copy number aberrations driving gene expression changes thought to underpin their malignant phenotypes. Here the authors integrate these features, finding and functionally validating 37 gene addictions among which they identify the mechanism of addiction to KIFC1, a potential selective drug target.Nirmesh PatelDaniel WeekesKonstantinos DrosopoulosPatrycja GazinskaElodie NoelMamun RashidHasan MirzaJelmar QuistFara Brasó-MaristanySumi MathewRiccardo FerroAna Mendes PereiraCynthia PrinceFarzana NoorErika Francesch-DomenechRebecca MarlowEmanuele de RinaldisAnita GrigoriadisSpiros LinardopoulosPierfrancesco MarraAndrew N. J. TuttNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nirmesh Patel Daniel Weekes Konstantinos Drosopoulos Patrycja Gazinska Elodie Noel Mamun Rashid Hasan Mirza Jelmar Quist Fara Brasó-Maristany Sumi Mathew Riccardo Ferro Ana Mendes Pereira Cynthia Prince Farzana Noor Erika Francesch-Domenech Rebecca Marlow Emanuele de Rinaldis Anita Grigoriadis Spiros Linardopoulos Pierfrancesco Marra Andrew N. J. Tutt Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
description	Triple negative breast cancers harbor multiple copy number aberrations driving gene expression changes thought to underpin their malignant phenotypes. Here the authors integrate these features, finding and functionally validating 37 gene addictions among which they identify the mechanism of addiction to KIFC1, a potential selective drug target.
format	article
author	Nirmesh Patel Daniel Weekes Konstantinos Drosopoulos Patrycja Gazinska Elodie Noel Mamun Rashid Hasan Mirza Jelmar Quist Fara Brasó-Maristany Sumi Mathew Riccardo Ferro Ana Mendes Pereira Cynthia Prince Farzana Noor Erika Francesch-Domenech Rebecca Marlow Emanuele de Rinaldis Anita Grigoriadis Spiros Linardopoulos Pierfrancesco Marra Andrew N. J. Tutt
author_facet	Nirmesh Patel Daniel Weekes Konstantinos Drosopoulos Patrycja Gazinska Elodie Noel Mamun Rashid Hasan Mirza Jelmar Quist Fara Brasó-Maristany Sumi Mathew Riccardo Ferro Ana Mendes Pereira Cynthia Prince Farzana Noor Erika Francesch-Domenech Rebecca Marlow Emanuele de Rinaldis Anita Grigoriadis Spiros Linardopoulos Pierfrancesco Marra Andrew N. J. Tutt
author_sort	Nirmesh Patel
title	Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
title_short	Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
title_full	Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
title_fullStr	Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
title_full_unstemmed	Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
title_sort	integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5040e6ddb1d140d09e37fbc06a8ca400
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Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer

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