White matter integrity in young medication-naïve bipolar II depressed adults

Abstract It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3...

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Autores principales:	Arthur Dun Ping Mak, Owen Ngo Wang Leung, Idy Wing Yi Chou, Sheila Lok Yiu Wong, Winnie Chiu-wing Chu, David Yeung, Suzanne Ho-wai So, Suk Ling Ma, Linda Chiu Wah Lam, Chi Ming Leung, Sing Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5041ca3bc94547ab85748fbe73003d9a
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spelling	oai:doaj.org-article:5041ca3bc94547ab85748fbe73003d9a2021-12-02T13:50:49ZWhite matter integrity in young medication-naïve bipolar II depressed adults10.1038/s41598-021-81355-92045-2322https://doaj.org/article/5041ca3bc94547ab85748fbe73003d9a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81355-9https://doaj.org/toc/2045-2322Abstract It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73–0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of $${F}_{B}$$ F B : 0.00073, 5.22, ηp2 = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.Arthur Dun Ping MakOwen Ngo Wang LeungIdy Wing Yi ChouSheila Lok Yiu WongWinnie Chiu-wing ChuDavid YeungSuzanne Ho-wai SoSuk Ling MaLinda Chiu Wah LamChi Ming LeungSing LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Arthur Dun Ping Mak Owen Ngo Wang Leung Idy Wing Yi Chou Sheila Lok Yiu Wong Winnie Chiu-wing Chu David Yeung Suzanne Ho-wai So Suk Ling Ma Linda Chiu Wah Lam Chi Ming Leung Sing Lee White matter integrity in young medication-naïve bipolar II depressed adults
description	Abstract It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73–0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of $${F}_{B}$$ F B : 0.00073, 5.22, ηp2 = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.
format	article
author	Arthur Dun Ping Mak Owen Ngo Wang Leung Idy Wing Yi Chou Sheila Lok Yiu Wong Winnie Chiu-wing Chu David Yeung Suzanne Ho-wai So Suk Ling Ma Linda Chiu Wah Lam Chi Ming Leung Sing Lee
author_facet	Arthur Dun Ping Mak Owen Ngo Wang Leung Idy Wing Yi Chou Sheila Lok Yiu Wong Winnie Chiu-wing Chu David Yeung Suzanne Ho-wai So Suk Ling Ma Linda Chiu Wah Lam Chi Ming Leung Sing Lee
author_sort	Arthur Dun Ping Mak
title	White matter integrity in young medication-naïve bipolar II depressed adults
title_short	White matter integrity in young medication-naïve bipolar II depressed adults
title_full	White matter integrity in young medication-naïve bipolar II depressed adults
title_fullStr	White matter integrity in young medication-naïve bipolar II depressed adults
title_full_unstemmed	White matter integrity in young medication-naïve bipolar II depressed adults
title_sort	white matter integrity in young medication-naïve bipolar ii depressed adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5041ca3bc94547ab85748fbe73003d9a
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White matter integrity in young medication-naïve bipolar II depressed adults

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