Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers

Guanidinium-containing macromolecules, such as arginine-rich peptides, have peculiar properties in their interactions with membranes, including efficient translocation. Here the authors show that cationic gold nanoparticles functionalized with guanidinium groups can specifically and nondisruptively...

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Autores principales: Lucía Morillas-Becerril, Sebastian Franco-Ulloa, Ilaria Fortunati, Roberto Marotta, Xiaohuan Sun, Giordano Zanoni, Marco De Vivo, Fabrizio Mancin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5045bf3f29fc455584e389dcd93af023
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Sumario:Guanidinium-containing macromolecules, such as arginine-rich peptides, have peculiar properties in their interactions with membranes, including efficient translocation. Here the authors show that cationic gold nanoparticles functionalized with guanidinium groups can specifically and nondisruptively interact with phospholipid bilayer membranes.