Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus
Abstract Type 2 diabetes mellitus (T2DM) increases cardiac inflammation which promotes the development of cardiac fibrosis. We sought to determine the impact of circadian disruption on the induction of hyperglycaemia, inflammation and cardiac fibrosis. Methods: Psammomys obesus (P. obesus) were expo...
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Nature Portfolio
2021
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oai:doaj.org-article:5047b3c7300242919ee2a6711a0e7ee62021-12-02T15:37:59ZCircadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus10.1038/s41598-021-89191-72045-2322https://doaj.org/article/5047b3c7300242919ee2a6711a0e7ee62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89191-7https://doaj.org/toc/2045-2322Abstract Type 2 diabetes mellitus (T2DM) increases cardiac inflammation which promotes the development of cardiac fibrosis. We sought to determine the impact of circadian disruption on the induction of hyperglycaemia, inflammation and cardiac fibrosis. Methods: Psammomys obesus (P. obesus) were exposed to neutral (12 h light:12 h dark) or short (5 h light:19 h dark) photoperiods and fed a low energy (LE) or high energy (HE) diet for 8 or 20 weeks. To determine daily rhythmicity, P. obesus were euthanised at 2, 8, 14, and 20 h after ‘lights on’. Results: P. obesus exposed to a short photoperiod for 8 and 20 weeks had impaired glucose tolerance following oral glucose tolerance testing, compared to a neutral photoperiod exposure. This occurred with both LE and HE diets but was more pronounced with the HE diet. Short photoperiod exposure also increased myocardial perivascular fibrosis after 20 weeks on LE (51%, P < 0.05) and HE (44%, P < 0.05) diets, when compared to groups with neutral photoperiod exposure. Short photoperiod exposure caused elevations in mRNA levels of hypertrophy gene Nppa (atrial natriuretic peptide) and hypertrophy transcription factors Gata4 and Mef2c in myocardial tissue after 8 weeks. Conclusion: Exposure to a short photoperiod causes impaired glucose tolerance in P. obesus that is exacerbated with HE diet and is accompanied by an induction in myocardial perivascular fibrosis.Victoria A. NankivellJoanne T. M. TanLaura A. WilsdonKaitlin R. MorrisonCarmel BiluPeter J. PsaltisPaul ZimmetNoga Kronfeld-SchorStephen J. NichollsChristina A. BursillAlex BrownNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Victoria A. Nankivell Joanne T. M. Tan Laura A. Wilsdon Kaitlin R. Morrison Carmel Bilu Peter J. Psaltis Paul Zimmet Noga Kronfeld-Schor Stephen J. Nicholls Christina A. Bursill Alex Brown Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus |
| description |
Abstract Type 2 diabetes mellitus (T2DM) increases cardiac inflammation which promotes the development of cardiac fibrosis. We sought to determine the impact of circadian disruption on the induction of hyperglycaemia, inflammation and cardiac fibrosis. Methods: Psammomys obesus (P. obesus) were exposed to neutral (12 h light:12 h dark) or short (5 h light:19 h dark) photoperiods and fed a low energy (LE) or high energy (HE) diet for 8 or 20 weeks. To determine daily rhythmicity, P. obesus were euthanised at 2, 8, 14, and 20 h after ‘lights on’. Results: P. obesus exposed to a short photoperiod for 8 and 20 weeks had impaired glucose tolerance following oral glucose tolerance testing, compared to a neutral photoperiod exposure. This occurred with both LE and HE diets but was more pronounced with the HE diet. Short photoperiod exposure also increased myocardial perivascular fibrosis after 20 weeks on LE (51%, P < 0.05) and HE (44%, P < 0.05) diets, when compared to groups with neutral photoperiod exposure. Short photoperiod exposure caused elevations in mRNA levels of hypertrophy gene Nppa (atrial natriuretic peptide) and hypertrophy transcription factors Gata4 and Mef2c in myocardial tissue after 8 weeks. Conclusion: Exposure to a short photoperiod causes impaired glucose tolerance in P. obesus that is exacerbated with HE diet and is accompanied by an induction in myocardial perivascular fibrosis. |
| format |
article |
| author |
Victoria A. Nankivell Joanne T. M. Tan Laura A. Wilsdon Kaitlin R. Morrison Carmel Bilu Peter J. Psaltis Paul Zimmet Noga Kronfeld-Schor Stephen J. Nicholls Christina A. Bursill Alex Brown |
| author_facet |
Victoria A. Nankivell Joanne T. M. Tan Laura A. Wilsdon Kaitlin R. Morrison Carmel Bilu Peter J. Psaltis Paul Zimmet Noga Kronfeld-Schor Stephen J. Nicholls Christina A. Bursill Alex Brown |
| author_sort |
Victoria A. Nankivell |
| title |
Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus |
| title_short |
Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus |
| title_full |
Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus |
| title_fullStr |
Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus |
| title_full_unstemmed |
Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus |
| title_sort |
circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in psammomys obesus |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5047b3c7300242919ee2a6711a0e7ee6 |
| work_keys_str_mv |
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