Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes

Darja KanducDepartment of Biochemistry and Molecular Biology, University of Bari, ItalyAbstract: We searched the primary sequence of influenza A H5N1 polyprotein for hexamer amino acid sequences shared with human proteins using the Protein International Resource database and the exact peptide matchi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Darja Kanduc
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5047f6c3e2f64fd1b5a5776f4f183bc7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5047f6c3e2f64fd1b5a5776f4f183bc7
record_format	dspace
spelling	oai:doaj.org-article:5047f6c3e2f64fd1b5a5776f4f183bc72021-12-02T07:12:39ZDescribing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes1177-54751177-5491https://doaj.org/article/5047f6c3e2f64fd1b5a5776f4f183bc72010-09-01T00:00:00Zhttp://www.dovepress.com/describing-the-hexapeptide-identity-platform-between-the-influenza-a-h-a5242https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Darja KanducDepartment of Biochemistry and Molecular Biology, University of Bari, ItalyAbstract: We searched the primary sequence of influenza A H5N1 polyprotein for hexamer amino acid sequences shared with human proteins using the Protein International Resource database and the exact peptide matching analysis program. We find that the viral polyprotein shares numerous hexapeptides with the human proteome. The human proteins involved in the viral overlap are represented by antigens associated with basic cell functions such as proliferation, development, and differentiation. Of special importance, many human proteins that share peptide sequences with influenza A polyprotein are antigens such as reelin, neurexin I-a, myosin-IXa, Bardet&ndash;Biedl syndrome 10 protein, Williams syndrome transcription factor, disrupted in schizophrenia 1 protein, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein, fragile X mental retardation 2 protein, and jouberin. That is, the viral-vs-human overlap involves human proteins that, when altered, have been reported to be potentially associated with multiple neurological disorders that can include autism, epilepsy, obesity, dystonia, ataxia&ndash;telangiectasia, amyotrophic lateral sclerosis, sensorineural deafness, sudden infant death syndrome, Charcot-Marie-Tooth disease, and myelination. The present data are discussed as a possible molecular basis for understanding influenza A viral escape from immunosurveillance and for defining anti-influenza immune-therapeutic approaches devoid of collateral adverse events.Keywords: peptide sharing, neurological disorders, host-pathogen relationships, viral escape from immunosurveillance Darja KanducDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2010, Iss default, Pp 245-261 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Darja Kanduc Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes
description	Darja KanducDepartment of Biochemistry and Molecular Biology, University of Bari, ItalyAbstract: We searched the primary sequence of influenza A H5N1 polyprotein for hexamer amino acid sequences shared with human proteins using the Protein International Resource database and the exact peptide matching analysis program. We find that the viral polyprotein shares numerous hexapeptides with the human proteome. The human proteins involved in the viral overlap are represented by antigens associated with basic cell functions such as proliferation, development, and differentiation. Of special importance, many human proteins that share peptide sequences with influenza A polyprotein are antigens such as reelin, neurexin I-a, myosin-IXa, Bardet&ndash;Biedl syndrome 10 protein, Williams syndrome transcription factor, disrupted in schizophrenia 1 protein, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein, fragile X mental retardation 2 protein, and jouberin. That is, the viral-vs-human overlap involves human proteins that, when altered, have been reported to be potentially associated with multiple neurological disorders that can include autism, epilepsy, obesity, dystonia, ataxia&ndash;telangiectasia, amyotrophic lateral sclerosis, sensorineural deafness, sudden infant death syndrome, Charcot-Marie-Tooth disease, and myelination. The present data are discussed as a possible molecular basis for understanding influenza A viral escape from immunosurveillance and for defining anti-influenza immune-therapeutic approaches devoid of collateral adverse events.Keywords: peptide sharing, neurological disorders, host-pathogen relationships, viral escape from immunosurveillance
format	article
author	Darja Kanduc
author_facet	Darja Kanduc
author_sort	Darja Kanduc
title	Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes
title_short	Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes
title_full	Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes
title_fullStr	Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes
title_full_unstemmed	Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes
title_sort	describing the hexapeptide identity platform between the influenza a h5n1 and homo sapiens proteomes
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/5047f6c3e2f64fd1b5a5776f4f183bc7
work_keys_str_mv	AT darjakanduc describingthehexapeptideidentityplatformbetweentheinfluenzaah5n1andhomosapiensproteomes
_version_	1718399568586997760

Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes

Ejemplares similares