Effect of DRD4 receptor −616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients

Abstract The dopamine D4 receptor (DRD4) promoter (−616; rs747302) has been associated with primary nocturnal enuresis (PNE); however, its relationship with neuroimaging has not been investigated. Therefore, we assessed the effects of the DRD4 −616 C/G single nucleotide polymorphism on the gray matt...

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Autores principales:	Bing Yu, Na Chang, Yao Lu, Hongwei Ma, Na Liu, Qiyong Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/504b7e9d739a43be9df2428c4039916c
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spelling	oai:doaj.org-article:504b7e9d739a43be9df2428c4039916c2021-12-02T15:04:56ZEffect of DRD4 receptor −616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients10.1038/s41598-017-01403-12045-2322https://doaj.org/article/504b7e9d739a43be9df2428c4039916c2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01403-1https://doaj.org/toc/2045-2322Abstract The dopamine D4 receptor (DRD4) promoter (−616; rs747302) has been associated with primary nocturnal enuresis (PNE); however, its relationship with neuroimaging has not been investigated. Therefore, we assessed the effects of the DRD4 −616 C/G single nucleotide polymorphism on the gray matter volume (GMV) and functional connectivity density (FCD) during resting-state functional magnetic resonance imaging in children with PNE using voxel-based morphometry and FCD methods. Genomic and imaging data were obtained from 97 children with PNE and 105 healthy controls. DRD4 −616 C/G was genotyped. Arousal from sleep (AS) was assessed on a scale of 1–8. Both the main effect of genotype and the group (PNE/control)-by-genotype interaction on GMV and FCD were calculated. Our results showed that C-allele carriers were associated with a higher AS, decreased GMV and FCD in the pregenual anterior cingulate cortex; children with PNE carrying the C allele exhibit decreased GMV and FCD in the thalamus; however, controls carrying the C allele exhibit increased FCD in the posterior cingulate cortex. These effects of genetic variation of the DRD4 locus may help us understand the genetic susceptibility of the DRD4 −616 C allele to PNE.Bing YuNa ChangYao LuHongwei MaNa LiuQiyong GuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bing Yu Na Chang Yao Lu Hongwei Ma Na Liu Qiyong Guo Effect of DRD4 receptor −616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients
description	Abstract The dopamine D4 receptor (DRD4) promoter (−616; rs747302) has been associated with primary nocturnal enuresis (PNE); however, its relationship with neuroimaging has not been investigated. Therefore, we assessed the effects of the DRD4 −616 C/G single nucleotide polymorphism on the gray matter volume (GMV) and functional connectivity density (FCD) during resting-state functional magnetic resonance imaging in children with PNE using voxel-based morphometry and FCD methods. Genomic and imaging data were obtained from 97 children with PNE and 105 healthy controls. DRD4 −616 C/G was genotyped. Arousal from sleep (AS) was assessed on a scale of 1–8. Both the main effect of genotype and the group (PNE/control)-by-genotype interaction on GMV and FCD were calculated. Our results showed that C-allele carriers were associated with a higher AS, decreased GMV and FCD in the pregenual anterior cingulate cortex; children with PNE carrying the C allele exhibit decreased GMV and FCD in the thalamus; however, controls carrying the C allele exhibit increased FCD in the posterior cingulate cortex. These effects of genetic variation of the DRD4 locus may help us understand the genetic susceptibility of the DRD4 −616 C allele to PNE.
format	article
author	Bing Yu Na Chang Yao Lu Hongwei Ma Na Liu Qiyong Guo
author_facet	Bing Yu Na Chang Yao Lu Hongwei Ma Na Liu Qiyong Guo
author_sort	Bing Yu
title	Effect of DRD4 receptor −616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients
title_short	Effect of DRD4 receptor −616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients
title_full	Effect of DRD4 receptor −616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients
title_fullStr	Effect of DRD4 receptor −616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients
title_full_unstemmed	Effect of DRD4 receptor −616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients
title_sort	effect of drd4 receptor −616 c/g polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/504b7e9d739a43be9df2428c4039916c
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Effect of DRD4 receptor −616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients

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