A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease

Nakatsuka et al. discover that the adipokine vaspin contributes to maintaining proximal tubular cell (PTC) homeostasis by ameliorating organelle stress. They find that upon internalization, vaspin interacts with the heat shock protein HSPA1L and that the proteins cooperate to prevent metabolic stres...

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Autores principales:	Atsuko Nakatsuka, Satoshi Yamaguchi, Jun Eguchi, Shigeru Kakuta, Yoichiro Iwakura, Hitoshi Sugiyama, Jun Wada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/504c98c3951846f684a8e569ad2b2f68
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spelling	oai:doaj.org-article:504c98c3951846f684a8e569ad2b2f682021-12-02T13:17:47ZA Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease10.1038/s42003-021-01902-y2399-3642https://doaj.org/article/504c98c3951846f684a8e569ad2b2f682021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01902-yhttps://doaj.org/toc/2399-3642Nakatsuka et al. discover that the adipokine vaspin contributes to maintaining proximal tubular cell (PTC) homeostasis by ameliorating organelle stress. They find that upon internalization, vaspin interacts with the heat shock protein HSPA1L and that the proteins cooperate to prevent metabolic stress-induced cellular injuries in PTCs.Atsuko NakatsukaSatoshi YamaguchiJun EguchiShigeru KakutaYoichiro IwakuraHitoshi SugiyamaJun WadaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Atsuko Nakatsuka Satoshi Yamaguchi Jun Eguchi Shigeru Kakuta Yoichiro Iwakura Hitoshi Sugiyama Jun Wada A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease
description	Nakatsuka et al. discover that the adipokine vaspin contributes to maintaining proximal tubular cell (PTC) homeostasis by ameliorating organelle stress. They find that upon internalization, vaspin interacts with the heat shock protein HSPA1L and that the proteins cooperate to prevent metabolic stress-induced cellular injuries in PTCs.
format	article
author	Atsuko Nakatsuka Satoshi Yamaguchi Jun Eguchi Shigeru Kakuta Yoichiro Iwakura Hitoshi Sugiyama Jun Wada
author_facet	Atsuko Nakatsuka Satoshi Yamaguchi Jun Eguchi Shigeru Kakuta Yoichiro Iwakura Hitoshi Sugiyama Jun Wada
author_sort	Atsuko Nakatsuka
title	A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease
title_short	A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease
title_full	A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease
title_fullStr	A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease
title_full_unstemmed	A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease
title_sort	vaspin–hspa1l complex protects proximal tubular cells from organelle stress in diabetic kidney disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/504c98c3951846f684a8e569ad2b2f68
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A Vaspin–HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease

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