Mantle cell leukemia as a cause of leukostasis

Mantle cell leukemia as a cause of leukostasis

Daniel Smith1, Christian Cable2, Cary Chisholm1, Walter Linz1, William Koss1, Sheila Dobin1, Edward Rappaport11Department of Pathology, 2Internal Medicine, Scott and White Healthcare/Texas A & M Health Science Center College of Medicine, Temple, TX, USAAbstract: A 72-year-old man was adm...

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Autores principales: Rappaport E, Dobin S, Koss W, Linz W, Chisholm C, Cable C, Smith D
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2011
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Diseases of the blood and blood-forming organs
RC633-647.5
Acceso en línea:https://doaj.org/article/5051c237c7094ab183ad2a2e8b064d99
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spelling oai:doaj.org-article:5051c237c7094ab183ad2a2e8b064d992021-12-02T01:46:23ZMantle cell leukemia as a cause of leukostasis1179-9889https://doaj.org/article/5051c237c7094ab183ad2a2e8b064d992011-04-01T00:00:00Zhttp://www.dovepress.com/mantle-cell-leukemia-as-a-cause-of-leukostasis-a7261https://doaj.org/toc/1179-9889Daniel Smith1, Christian Cable2, Cary Chisholm1, Walter Linz1, William Koss1, Sheila Dobin1, Edward Rappaport11Department of Pathology, 2Internal Medicine, Scott and White Healthcare/Texas A & M Health Science Center College of Medicine, Temple, TX, USAAbstract: A 72-year-old man was admitted with hypoxemic respiratory distress. Given a white blood cell count of 600 × 109/L and symptoms of leukostasis, emergency leukapheresis was initiated. The white blood cell count immediately after the first leukapheresis was paradoxically increased to over 700 × 109/L. Peripheral blood smear findings showed morphologically immature mononuclear cells and numerous circulating mitotic figures. Initial flow cytometry results showed a lambda light chain-restricted B lymphoid population positive for CD20, CD19, CD5, and FMC-7, and negative for TdT, CD10, CD23, CD34, CD117, and myeloid markers, suggesting classification as a blastoid variant of mantle cell lymphoma in a leukemic phase. Subsequent testing using DNA fluorescence in situ hybridization was positive for t(11;14), confirming the diagnosis of mantle cell leukemia. Although mantle cell lymphoma occasionally transforms or can even present as leukemia (leukocytes >40 × 109/L), it is rare for it to present with such profound leukocytosis and an overwhelming number of pleomorphic/blastoid forms. Although morphology suggested acute lymphoblastic leukemia, a more specific diagnosis of blastoid variant mantle cell lymphoma was obtained in 12 hours by applying complementary techniques of flow cytometry and rapid cytogenetics.Keywords: mantle cell lymphoma, chemotherapy, leukapheresis, lymphocytic leukemiaRappaport EDobin SKoss WLinz WChisholm CCable CSmith DDove Medical PressarticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood and Lymphatic Cancer: Targets and Therapy, Vol 2011, Iss default, Pp 5-8 (2011)
institution DOAJ
collection DOAJ
language EN
topic Diseases of the blood and blood-forming organs
RC633-647.5
spellingShingle Diseases of the blood and blood-forming organs
RC633-647.5
Rappaport E
Dobin S
Koss W
Linz W
Chisholm C
Cable C
Smith D
Mantle cell leukemia as a cause of leukostasis
description Daniel Smith1, Christian Cable2, Cary Chisholm1, Walter Linz1, William Koss1, Sheila Dobin1, Edward Rappaport11Department of Pathology, 2Internal Medicine, Scott and White Healthcare/Texas A & M Health Science Center College of Medicine, Temple, TX, USAAbstract: A 72-year-old man was admitted with hypoxemic respiratory distress. Given a white blood cell count of 600 × 109/L and symptoms of leukostasis, emergency leukapheresis was initiated. The white blood cell count immediately after the first leukapheresis was paradoxically increased to over 700 × 109/L. Peripheral blood smear findings showed morphologically immature mononuclear cells and numerous circulating mitotic figures. Initial flow cytometry results showed a lambda light chain-restricted B lymphoid population positive for CD20, CD19, CD5, and FMC-7, and negative for TdT, CD10, CD23, CD34, CD117, and myeloid markers, suggesting classification as a blastoid variant of mantle cell lymphoma in a leukemic phase. Subsequent testing using DNA fluorescence in situ hybridization was positive for t(11;14), confirming the diagnosis of mantle cell leukemia. Although mantle cell lymphoma occasionally transforms or can even present as leukemia (leukocytes >40 × 109/L), it is rare for it to present with such profound leukocytosis and an overwhelming number of pleomorphic/blastoid forms. Although morphology suggested acute lymphoblastic leukemia, a more specific diagnosis of blastoid variant mantle cell lymphoma was obtained in 12 hours by applying complementary techniques of flow cytometry and rapid cytogenetics.Keywords: mantle cell lymphoma, chemotherapy, leukapheresis, lymphocytic leukemia
format article
author Rappaport E
Dobin S
Koss W
Linz W
Chisholm C
Cable C
Smith D
author_facet Rappaport E
Dobin S
Koss W
Linz W
Chisholm C
Cable C
Smith D
author_sort Rappaport E
title Mantle cell leukemia as a cause of leukostasis
title_short Mantle cell leukemia as a cause of leukostasis
title_full Mantle cell leukemia as a cause of leukostasis
title_fullStr Mantle cell leukemia as a cause of leukostasis
title_full_unstemmed Mantle cell leukemia as a cause of leukostasis
title_sort mantle cell leukemia as a cause of leukostasis
publisher Dove Medical Press
publishDate 2011
url https://doaj.org/article/5051c237c7094ab183ad2a2e8b064d99
work_keys_str_mv AT rappaporte mantlecellleukemiaasacauseofleukostasis
AT dobins mantlecellleukemiaasacauseofleukostasis
AT kossw mantlecellleukemiaasacauseofleukostasis
AT linzw mantlecellleukemiaasacauseofleukostasis
AT chisholmc mantlecellleukemiaasacauseofleukostasis
AT cablec mantlecellleukemiaasacauseofleukostasis
AT smithd mantlecellleukemiaasacauseofleukostasis
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