Postnatal DNA demethylation and its role in tissue maturation

Postnatal DNA demethylation and its role in tissue maturation

Here the authors show that a large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play a major role in the regulation of gene expression and tissue maturation in the liver.

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Autores principales: Yitzhak Reizel, Ofra Sabag, Yael Skversky, Adam Spiro, Benjamin Steinberg, Diana Bernstein, Amber Wang, Julia Kieckhaefer, Catherine Li, Eli Pikarsky, Rena Levin-Klein, Alon Goren, Klaus Rajewsky, Klaus H. Kaestner, Howard Cedar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/50520c8d9e7d4a71beda66e83fbcd1e0
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spelling oai:doaj.org-article:50520c8d9e7d4a71beda66e83fbcd1e02021-12-02T17:31:43ZPostnatal DNA demethylation and its role in tissue maturation10.1038/s41467-018-04456-62041-1723https://doaj.org/article/50520c8d9e7d4a71beda66e83fbcd1e02018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04456-6https://doaj.org/toc/2041-1723Here the authors show that a large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play a major role in the regulation of gene expression and tissue maturation in the liver.Yitzhak ReizelOfra SabagYael SkverskyAdam SpiroBenjamin SteinbergDiana BernsteinAmber WangJulia KieckhaeferCatherine LiEli PikarskyRena Levin-KleinAlon GorenKlaus RajewskyKlaus H. KaestnerHoward CedarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yitzhak Reizel
Ofra Sabag
Yael Skversky
Adam Spiro
Benjamin Steinberg
Diana Bernstein
Amber Wang
Julia Kieckhaefer
Catherine Li
Eli Pikarsky
Rena Levin-Klein
Alon Goren
Klaus Rajewsky
Klaus H. Kaestner
Howard Cedar
Postnatal DNA demethylation and its role in tissue maturation
description Here the authors show that a large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play a major role in the regulation of gene expression and tissue maturation in the liver.
format article
author Yitzhak Reizel
Ofra Sabag
Yael Skversky
Adam Spiro
Benjamin Steinberg
Diana Bernstein
Amber Wang
Julia Kieckhaefer
Catherine Li
Eli Pikarsky
Rena Levin-Klein
Alon Goren
Klaus Rajewsky
Klaus H. Kaestner
Howard Cedar
author_facet Yitzhak Reizel
Ofra Sabag
Yael Skversky
Adam Spiro
Benjamin Steinberg
Diana Bernstein
Amber Wang
Julia Kieckhaefer
Catherine Li
Eli Pikarsky
Rena Levin-Klein
Alon Goren
Klaus Rajewsky
Klaus H. Kaestner
Howard Cedar
author_sort Yitzhak Reizel
title Postnatal DNA demethylation and its role in tissue maturation
title_short Postnatal DNA demethylation and its role in tissue maturation
title_full Postnatal DNA demethylation and its role in tissue maturation
title_fullStr Postnatal DNA demethylation and its role in tissue maturation
title_full_unstemmed Postnatal DNA demethylation and its role in tissue maturation
title_sort postnatal dna demethylation and its role in tissue maturation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/50520c8d9e7d4a71beda66e83fbcd1e0
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AT ofrasabag postnataldnademethylationanditsroleintissuematuration
AT yaelskversky postnataldnademethylationanditsroleintissuematuration
AT adamspiro postnataldnademethylationanditsroleintissuematuration
AT benjaminsteinberg postnataldnademethylationanditsroleintissuematuration
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AT renalevinklein postnataldnademethylationanditsroleintissuematuration
AT alongoren postnataldnademethylationanditsroleintissuematuration
AT klausrajewsky postnataldnademethylationanditsroleintissuematuration
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