Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DR and DQ genes in two Russian populations of Moscow and Vologda regions

Aim. To consider association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DRB1 HLA-DQB1, and DQA1 genes in two Russian populations of Moscow (MP) and Vologda (VP) regions. Materials and methods. Identification of alleles of HLA-DRB1 HLA-DQB1, and DQA1 genes in 138 patients wi...

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Autores principales:	Tamara Leonidovna Kuraeva, M N Kashenin, M N Boldyreva, N M Tsitlidze, A N Nikitin, Sergey Alexandrovich Prokofiev, Lyubov' Iosifovna Zilberman, Valentina Alexandrovna Peterkova, Valery Vyacheslavovich Nosikov, Ivan Ivanovich Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	type 1 diabetes mellitus allele association vologda population moscow population relative risk Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/5054aad6fb814865a3c7623e5786bb32
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spelling	oai:doaj.org-article:5054aad6fb814865a3c7623e5786bb322021-11-14T09:00:13ZAssociation of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DR and DQ genes in two Russian populations of Moscow and Vologda regions2072-03512072-037810.14341/2072-0351-5394https://doaj.org/article/5054aad6fb814865a3c7623e5786bb322009-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5394https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To consider association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DRB1 HLA-DQB1, and DQA1 genes in two Russian populations of Moscow (MP) and Vologda (VP) regions. Materials and methods. Identification of alleles of HLA-DRB1 HLA-DQB1, and DQA1 genes in 138 patients with type 1 diabetes and a random sample of 242 subjects from the local population (residents in at least three successive generations) of the Vologda region, 204 patients and a random sample of 300 subjects from the city of Moscow and Moscow region. Results. MP and VP exhibited identical predisposing alleles. The occurrence of DRB14 (RR=5.96 and 3.93 in MP and VP respectively), DRB117 (RR=4.33 and 4.23), DQA10301 (RR=5.70 and 3.66), DQB10201, (RR=2.06 and 1.77), DQB1* 0302 (RR=7.10 and 3.95), DQB1* 0304 (RR=8.94 and 19.98) alleles was significantly higher in DM1 patients. The following protective alleles were identified in MP and VP respectively: DRB17 (RR=0.37 and 0.18), DRB111 (RR=0.12 and 0.21), DRB113 (RR=0.09 and 0.26), DRB115 (RR=0.23 and 0.04), DQA10102 (RR=0.29 and 0.23), DQA10103 (RR=0.13 and 0.23), DQA10201 (RR=0.37 and 0.17), DQb10301 (RR=0.16 and 0.24), and DQB10602/8 (RR=0.10 and 0.13). Conclusion. ?New? associations unknown in other populations (e.g. DQB10304) were revealed, besides the majority of classical predisposing and protective alleles characteristic of European populations. DQB1*0304 proved the strongest predisposing allele in MP and especially in VP. These data suggest different contribution of predisposing alleles to the development of DM1 in individual populations.Tamara Leonidovna KuraevaM N KasheninM N Boldyreva,N M TsitlidzeA N NikitinSergey Alexandrovich ProkofievLyubov' Iosifovna ZilbermanValentina Alexandrovna PeterkovaValery Vyacheslavovich NosikovIvan Ivanovich DedovEndocrinology Research Centrearticletype 1 diabetes mellitusalleleassociationvologda populationmoscow populationrelative riskNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 2, Pp 28-32 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes mellitus allele association vologda population moscow population relative risk Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes mellitus allele association vologda population moscow population relative risk Nutritional diseases. Deficiency diseases RC620-627 Tamara Leonidovna Kuraeva M N Kashenin M N Boldyreva, N M Tsitlidze A N Nikitin Sergey Alexandrovich Prokofiev Lyubov' Iosifovna Zilberman Valentina Alexandrovna Peterkova Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DR and DQ genes in two Russian populations of Moscow and Vologda regions
description	Aim. To consider association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DRB1 HLA-DQB1, and DQA1 genes in two Russian populations of Moscow (MP) and Vologda (VP) regions. Materials and methods. Identification of alleles of HLA-DRB1 HLA-DQB1, and DQA1 genes in 138 patients with type 1 diabetes and a random sample of 242 subjects from the local population (residents in at least three successive generations) of the Vologda region, 204 patients and a random sample of 300 subjects from the city of Moscow and Moscow region. Results. MP and VP exhibited identical predisposing alleles. The occurrence of DRB14 (RR=5.96 and 3.93 in MP and VP respectively), DRB117 (RR=4.33 and 4.23), DQA10301 (RR=5.70 and 3.66), DQB10201, (RR=2.06 and 1.77), DQB1* 0302 (RR=7.10 and 3.95), DQB1* 0304 (RR=8.94 and 19.98) alleles was significantly higher in DM1 patients. The following protective alleles were identified in MP and VP respectively: DRB17 (RR=0.37 and 0.18), DRB111 (RR=0.12 and 0.21), DRB113 (RR=0.09 and 0.26), DRB115 (RR=0.23 and 0.04), DQA10102 (RR=0.29 and 0.23), DQA10103 (RR=0.13 and 0.23), DQA10201 (RR=0.37 and 0.17), DQb10301 (RR=0.16 and 0.24), and DQB10602/8 (RR=0.10 and 0.13). Conclusion. ?New? associations unknown in other populations (e.g. DQB10304) were revealed, besides the majority of classical predisposing and protective alleles characteristic of European populations. DQB1*0304 proved the strongest predisposing allele in MP and especially in VP. These data suggest different contribution of predisposing alleles to the development of DM1 in individual populations.
format	article
author	Tamara Leonidovna Kuraeva M N Kashenin M N Boldyreva, N M Tsitlidze A N Nikitin Sergey Alexandrovich Prokofiev Lyubov' Iosifovna Zilberman Valentina Alexandrovna Peterkova Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov
author_facet	Tamara Leonidovna Kuraeva M N Kashenin M N Boldyreva, N M Tsitlidze A N Nikitin Sergey Alexandrovich Prokofiev Lyubov' Iosifovna Zilberman Valentina Alexandrovna Peterkova Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov
author_sort	Tamara Leonidovna Kuraeva
title	Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DR and DQ genes in two Russian populations of Moscow and Vologda regions
title_short	Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DR and DQ genes in two Russian populations of Moscow and Vologda regions
title_full	Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DR and DQ genes in two Russian populations of Moscow and Vologda regions
title_fullStr	Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DR and DQ genes in two Russian populations of Moscow and Vologda regions
title_full_unstemmed	Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DR and DQ genes in two Russian populations of Moscow and Vologda regions
title_sort	association of type 1 diabetes mellitus (dm1) with polymorphous alleles of hla-dr and dq genes in two russian populations of moscow and vologda regions
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/5054aad6fb814865a3c7623e5786bb32
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Association of type 1 diabetes mellitus (DM1) with polymorphous alleles of HLA-DR and DQ genes in two Russian populations of Moscow and Vologda regions

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