Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma

Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma

Abstract Intraocular medulloepithelioma (IO-MEPL) is a rare embryonal ocular neoplasm, prevalently occurring in children. IO-MEPLs share histomorphological features with CNS embryonal tumors with multilayered rosettes (ETMRs), referred to as intracranial medulloepitheliomas. While Sonic hedgehog (SH...

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Main Authors: Matthias Dottermusch, Piotr Sumisławski, Julia Krevet, Maximilian Middelkamp, Hannah Voß, Bente Siebels, Harald Bartsch, Karl Sotlar, Peter Meyer, Stephan Frank, Andrey Korshunov, Markus Glatzel, Ulrich Schüller, Julia E. Neumann
Format: article
Language:EN
Published: Nature Publishing Group 2021
Subjects:
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/5056055f68924b4582e954273d6ffd22
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https://doaj.org/article/5056055f68924b4582e954273d6ffd22

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