Repetitive magnetic stimulation induces plasticity of inhibitory synapses

Repetitive transcranial magnetic stimulation (rTMS) is widely used as a therapeutic tool yet its effect on inhibitory networks in the brain has not been studied. Here, the authors demonstrate that 10Hz rTMS specifically reduces dendritic inhibition onto pyramidal neurons accompanied by remodeling of...

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Autores principales: Maximilian Lenz, Christos Galanis, Florian Müller-Dahlhaus, Alexander Opitz, Corette J. Wierenga, Gábor Szabó, Ulf Ziemann, Thomas Deller, Klaus Funke, Andreas Vlachos
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/505f07b110f24549adb1c8aaaa650c29
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spelling oai:doaj.org-article:505f07b110f24549adb1c8aaaa650c292021-12-02T14:39:30ZRepetitive magnetic stimulation induces plasticity of inhibitory synapses10.1038/ncomms100202041-1723https://doaj.org/article/505f07b110f24549adb1c8aaaa650c292016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10020https://doaj.org/toc/2041-1723Repetitive transcranial magnetic stimulation (rTMS) is widely used as a therapeutic tool yet its effect on inhibitory networks in the brain has not been studied. Here, the authors demonstrate that 10Hz rTMS specifically reduces dendritic inhibition onto pyramidal neurons accompanied by remodeling of postsynaptic gephyrin clusters.Maximilian LenzChristos GalanisFlorian Müller-DahlhausAlexander OpitzCorette J. WierengaGábor SzabóUlf ZiemannThomas DellerKlaus FunkeAndreas VlachosNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Maximilian Lenz
Christos Galanis
Florian Müller-Dahlhaus
Alexander Opitz
Corette J. Wierenga
Gábor Szabó
Ulf Ziemann
Thomas Deller
Klaus Funke
Andreas Vlachos
Repetitive magnetic stimulation induces plasticity of inhibitory synapses
description Repetitive transcranial magnetic stimulation (rTMS) is widely used as a therapeutic tool yet its effect on inhibitory networks in the brain has not been studied. Here, the authors demonstrate that 10Hz rTMS specifically reduces dendritic inhibition onto pyramidal neurons accompanied by remodeling of postsynaptic gephyrin clusters.
format article
author Maximilian Lenz
Christos Galanis
Florian Müller-Dahlhaus
Alexander Opitz
Corette J. Wierenga
Gábor Szabó
Ulf Ziemann
Thomas Deller
Klaus Funke
Andreas Vlachos
author_facet Maximilian Lenz
Christos Galanis
Florian Müller-Dahlhaus
Alexander Opitz
Corette J. Wierenga
Gábor Szabó
Ulf Ziemann
Thomas Deller
Klaus Funke
Andreas Vlachos
author_sort Maximilian Lenz
title Repetitive magnetic stimulation induces plasticity of inhibitory synapses
title_short Repetitive magnetic stimulation induces plasticity of inhibitory synapses
title_full Repetitive magnetic stimulation induces plasticity of inhibitory synapses
title_fullStr Repetitive magnetic stimulation induces plasticity of inhibitory synapses
title_full_unstemmed Repetitive magnetic stimulation induces plasticity of inhibitory synapses
title_sort repetitive magnetic stimulation induces plasticity of inhibitory synapses
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/505f07b110f24549adb1c8aaaa650c29
work_keys_str_mv AT maximilianlenz repetitivemagneticstimulationinducesplasticityofinhibitorysynapses
AT christosgalanis repetitivemagneticstimulationinducesplasticityofinhibitorysynapses
AT florianmullerdahlhaus repetitivemagneticstimulationinducesplasticityofinhibitorysynapses
AT alexanderopitz repetitivemagneticstimulationinducesplasticityofinhibitorysynapses
AT corettejwierenga repetitivemagneticstimulationinducesplasticityofinhibitorysynapses
AT gaborszabo repetitivemagneticstimulationinducesplasticityofinhibitorysynapses
AT ulfziemann repetitivemagneticstimulationinducesplasticityofinhibitorysynapses
AT thomasdeller repetitivemagneticstimulationinducesplasticityofinhibitorysynapses
AT klausfunke repetitivemagneticstimulationinducesplasticityofinhibitorysynapses
AT andreasvlachos repetitivemagneticstimulationinducesplasticityofinhibitorysynapses
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