Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins

Abstract The mitophagy receptor Nix interacts with LC3/GABARAP proteins, targeting mitochondria into autophagosomes for degradation. Here we present evidence for phosphorylation-driven regulation of the Nix:LC3B interaction. Isothermal titration calorimetry and NMR indicate a ~100 fold enhanced affi...

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Main Authors: Vladimir V. Rogov, Hironori Suzuki, Mija Marinković, Verena Lang, Ryuichi Kato, Masato Kawasaki, Maja Buljubašić, Matilda Šprung, Natalia Rogova, Soichi Wakatsuki, Anne Hamacher-Brady, Volker Dötsch, Ivan Dikic, Nathan R. Brady, Ivana Novak
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/505fa4ea976e48f19f058f1285520910
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https://doaj.org/article/505fa4ea976e48f19f058f1285520910

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