Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.

<h4>Background</h4>Outbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis.<h4>Methods</h4>This study is a detailed report on the disease progression of acute Chagas disease i...

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Autores principales:	Claudilson J C Bastos, Roque Aras, Gildo Mota, Francisco Reis, Juarez Pereira Dias, Robson Silva de Jesus, Miralba Silva Freire, Eline G de Araújo, Juliana Prazeres, Maria Fernanda Rios Grassi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/50628ffcf49e4e63943ad229b0daa7f3
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spelling	oai:doaj.org-article:50628ffcf49e4e63943ad229b0daa7f32021-12-02T20:24:26ZClinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.1935-27271935-273510.1371/journal.pntd.0000711https://doaj.org/article/50628ffcf49e4e63943ad229b0daa7f32010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20559542/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Outbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis.<h4>Methods</h4>This study is a detailed report on the disease progression of acute Chagas disease in 13 patients who were infected during two micro-outbreaks in two northeastern Brazilian towns. Clinical outcomes as well as EKG and ECHO results are described, both before and after benznidazole treatment.<h4>Results</h4>Fever and dyspnea were the most frequent symptoms observed. Other clinical findings included myalgia, periorbital edema, headache and systolic murmur. Two patients died of cardiac failure before receiving benznidazole treatment. EKG and ECHO findings frequently showed a disturbance in ventricular repolarization and pericardial effusion. Ventricular dysfunction (ejection fraction <55%) was present in 27.3% of patients. After treatment, EKG readings normalized in 91.7% of patients. Ventricular repolarization abnormalities persisted in 50% of the patients, while sinus bradycardia was observed in 18%. The systolic ejection fraction normalized in two out of three patients with initially depressed ventricular function, while pericardial effusion disappeared.<h4>Conclusions</h4>Myocarditis is frequently found and potentially severe in patients with acute Chagas disease. Benznidazole treatment may improve clinical symptoms, as well as EKG and ECHO findings.Claudilson J C BastosRoque ArasGildo MotaFrancisco ReisJuarez Pereira DiasRobson Silva de JesusMiralba Silva FreireEline G de AraújoJuliana PrazeresMaria Fernanda Rios GrassiPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 4, Iss 6, p e711 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Claudilson J C Bastos Roque Aras Gildo Mota Francisco Reis Juarez Pereira Dias Robson Silva de Jesus Miralba Silva Freire Eline G de Araújo Juliana Prazeres Maria Fernanda Rios Grassi Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.
description	<h4>Background</h4>Outbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis.<h4>Methods</h4>This study is a detailed report on the disease progression of acute Chagas disease in 13 patients who were infected during two micro-outbreaks in two northeastern Brazilian towns. Clinical outcomes as well as EKG and ECHO results are described, both before and after benznidazole treatment.<h4>Results</h4>Fever and dyspnea were the most frequent symptoms observed. Other clinical findings included myalgia, periorbital edema, headache and systolic murmur. Two patients died of cardiac failure before receiving benznidazole treatment. EKG and ECHO findings frequently showed a disturbance in ventricular repolarization and pericardial effusion. Ventricular dysfunction (ejection fraction <55%) was present in 27.3% of patients. After treatment, EKG readings normalized in 91.7% of patients. Ventricular repolarization abnormalities persisted in 50% of the patients, while sinus bradycardia was observed in 18%. The systolic ejection fraction normalized in two out of three patients with initially depressed ventricular function, while pericardial effusion disappeared.<h4>Conclusions</h4>Myocarditis is frequently found and potentially severe in patients with acute Chagas disease. Benznidazole treatment may improve clinical symptoms, as well as EKG and ECHO findings.
format	article
author	Claudilson J C Bastos Roque Aras Gildo Mota Francisco Reis Juarez Pereira Dias Robson Silva de Jesus Miralba Silva Freire Eline G de Araújo Juliana Prazeres Maria Fernanda Rios Grassi
author_facet	Claudilson J C Bastos Roque Aras Gildo Mota Francisco Reis Juarez Pereira Dias Robson Silva de Jesus Miralba Silva Freire Eline G de Araújo Juliana Prazeres Maria Fernanda Rios Grassi
author_sort	Claudilson J C Bastos
title	Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.
title_short	Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.
title_full	Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.
title_fullStr	Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.
title_full_unstemmed	Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.
title_sort	clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern brazil.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/50628ffcf49e4e63943ad229b0daa7f3
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Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil.

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