Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial

Abstract Gut mucosal barrier injury is common following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and associated with poor clinical outcomes. Diet is critical for microbial diversity, but whether nutritional support affects microbiota and outcome after allo-HSCT is unknown. We p...

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Autores principales:	Kristin J. Skaarud, Johannes R. Hov, Simen H. Hansen, Martin Kummen, Jørgen Valeur, Ingebjørg Seljeflot, Asta Bye, Vemund Paulsen, Knut E. A. Lundin, Marius Trøseid, Geir E. Tjønnfjord, Per Ole Iversen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/506291e3837948b684d37c1e58ee93fd
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spelling	oai:doaj.org-article:506291e3837948b684d37c1e58ee93fd2021-12-02T15:56:57ZMortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial10.1038/s41598-021-90976-z2045-2322https://doaj.org/article/506291e3837948b684d37c1e58ee93fd2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90976-zhttps://doaj.org/toc/2045-2322Abstract Gut mucosal barrier injury is common following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and associated with poor clinical outcomes. Diet is critical for microbial diversity, but whether nutritional support affects microbiota and outcome after allo-HSCT is unknown. We present a secondary analysis of a randomized controlled nutritional intervention trial during allo-HSCT. We investigated if the intervention influenced gut microbiota, short-chain fatty acids (SCFAs), and markers of gut barrier functions, and if these parameters were associated with clinical outcomes. Fecal specimens were available from 47 recipients, and subjected to 16S rRNA gene sequencing. We found no significant differences between the intervention group and controls in investigated parameters. We observed a major depletion of microbiota, SCFAs, and altered markers of gut barrier function from baseline to 3 weeks post-transplant. One-year mortality was significantly higher in patients with lower diversity at 3 weeks post-HSCT, but not related to diversity at baseline. The relative abundance of Blautia genus at 3 weeks was higher in survivors. Fecal propionic acid was associated with survival. Markers of gut barrier functions were less strongly associated with clinical outcomes. Possibly, other strategies than dietary intervention are needed to prevent negative effects of gut microbiota and clinical outcomes after allo-HSCT. ClinicalTrials.gov (NCT01181076).Kristin J. SkaarudJohannes R. HovSimen H. HansenMartin KummenJørgen ValeurIngebjørg SeljeflotAsta ByeVemund PaulsenKnut E. A. LundinMarius TrøseidGeir E. TjønnfjordPer Ole IversenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kristin J. Skaarud Johannes R. Hov Simen H. Hansen Martin Kummen Jørgen Valeur Ingebjørg Seljeflot Asta Bye Vemund Paulsen Knut E. A. Lundin Marius Trøseid Geir E. Tjønnfjord Per Ole Iversen Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
description	Abstract Gut mucosal barrier injury is common following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and associated with poor clinical outcomes. Diet is critical for microbial diversity, but whether nutritional support affects microbiota and outcome after allo-HSCT is unknown. We present a secondary analysis of a randomized controlled nutritional intervention trial during allo-HSCT. We investigated if the intervention influenced gut microbiota, short-chain fatty acids (SCFAs), and markers of gut barrier functions, and if these parameters were associated with clinical outcomes. Fecal specimens were available from 47 recipients, and subjected to 16S rRNA gene sequencing. We found no significant differences between the intervention group and controls in investigated parameters. We observed a major depletion of microbiota, SCFAs, and altered markers of gut barrier function from baseline to 3 weeks post-transplant. One-year mortality was significantly higher in patients with lower diversity at 3 weeks post-HSCT, but not related to diversity at baseline. The relative abundance of Blautia genus at 3 weeks was higher in survivors. Fecal propionic acid was associated with survival. Markers of gut barrier functions were less strongly associated with clinical outcomes. Possibly, other strategies than dietary intervention are needed to prevent negative effects of gut microbiota and clinical outcomes after allo-HSCT. ClinicalTrials.gov (NCT01181076).
format	article
author	Kristin J. Skaarud Johannes R. Hov Simen H. Hansen Martin Kummen Jørgen Valeur Ingebjørg Seljeflot Asta Bye Vemund Paulsen Knut E. A. Lundin Marius Trøseid Geir E. Tjønnfjord Per Ole Iversen
author_facet	Kristin J. Skaarud Johannes R. Hov Simen H. Hansen Martin Kummen Jørgen Valeur Ingebjørg Seljeflot Asta Bye Vemund Paulsen Knut E. A. Lundin Marius Trøseid Geir E. Tjønnfjord Per Ole Iversen
author_sort	Kristin J. Skaarud
title	Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
title_short	Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
title_full	Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
title_fullStr	Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
title_full_unstemmed	Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
title_sort	mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/506291e3837948b684d37c1e58ee93fd
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Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial

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