Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines

The Pictet-Spengler condensation of β-arylethylamine and carbonyl compounds is an important step in the synthesis of bioactive alkaloids. Here, the authors report a Pictet-Spengler reaction between dopamine and unactivated ketones catalysed by norcoclaurine synthase and its engineered variants.

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Autores principales:	Benjamin R. Lichman, Jianxiong Zhao, Helen C. Hailes, John M. Ward
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5064c200fc83450fa59809ac2239395e
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spelling	oai:doaj.org-article:5064c200fc83450fa59809ac2239395e2021-12-02T14:41:11ZEnzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines10.1038/ncomms148832041-1723https://doaj.org/article/5064c200fc83450fa59809ac2239395e2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14883https://doaj.org/toc/2041-1723The Pictet-Spengler condensation of β-arylethylamine and carbonyl compounds is an important step in the synthesis of bioactive alkaloids. Here, the authors report a Pictet-Spengler reaction between dopamine and unactivated ketones catalysed by norcoclaurine synthase and its engineered variants.Benjamin R. LichmanJianxiong ZhaoHelen C. HailesJohn M. WardNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin R. Lichman Jianxiong Zhao Helen C. Hailes John M. Ward Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines
description	The Pictet-Spengler condensation of β-arylethylamine and carbonyl compounds is an important step in the synthesis of bioactive alkaloids. Here, the authors report a Pictet-Spengler reaction between dopamine and unactivated ketones catalysed by norcoclaurine synthase and its engineered variants.
format	article
author	Benjamin R. Lichman Jianxiong Zhao Helen C. Hailes John M. Ward
author_facet	Benjamin R. Lichman Jianxiong Zhao Helen C. Hailes John M. Ward
author_sort	Benjamin R. Lichman
title	Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines
title_short	Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines
title_full	Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines
title_fullStr	Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines
title_full_unstemmed	Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines
title_sort	enzyme catalysed pictet-spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5064c200fc83450fa59809ac2239395e
work_keys_str_mv	AT benjaminrlichman enzymecatalysedpictetspenglerformationofchiral11disubstitutedandspirotetrahydroisoquinolines AT jianxiongzhao enzymecatalysedpictetspenglerformationofchiral11disubstitutedandspirotetrahydroisoquinolines AT helenchailes enzymecatalysedpictetspenglerformationofchiral11disubstitutedandspirotetrahydroisoquinolines AT johnmward enzymecatalysedpictetspenglerformationofchiral11disubstitutedandspirotetrahydroisoquinolines
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Enzyme catalysed Pictet-Spengler formation of chiral 1,1’-disubstituted- and spiro-tetrahydroisoquinolines

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