Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study

Abstract Limited information is available on the effect of hypertriglyceridemia–waist (HTGW) combination and its dynamic status on the risk of type 2 diabetes mellitus (T2DM) in rural China. A cohort of 12,086 participants 18 to 92 years old was retained in this study. Kaplan-Meier analysis yielded...

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Autores principales:	Yongcheng Ren, Yu Liu, Xizhuo Sun, Kunpeng Deng, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yang Zhao, Junmei Zhou, Chengyi Han, Hongyan Zhang, Xiangyu Yang, Xinping Luo, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Ming Zhang, Dongsheng Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/50665be66df746a393c943bbfefabb6d
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spelling	oai:doaj.org-article:50665be66df746a393c943bbfefabb6d2021-12-02T15:05:48ZHypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study10.1038/s41598-017-09136-x2045-2322https://doaj.org/article/50665be66df746a393c943bbfefabb6d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09136-xhttps://doaj.org/toc/2045-2322Abstract Limited information is available on the effect of hypertriglyceridemia–waist (HTGW) combination and its dynamic status on the risk of type 2 diabetes mellitus (T2DM) in rural China. A cohort of 12,086 participants 18 to 92 years old was retained in this study. Kaplan-Meier analysis yielded the cumulative incidence of T2DM for each phenotype group (based on TG level and waist circumference [WC] at baseline). Cox regression yielded hazard ratios relating HTGW (based on TG level and WC at baseline and follow-up) to risk of developing T2DM. After a median follow-up of 6.0 years (71,432 person-years of follow-up), T2DM developed in 621 participants. For HTGW participants, the incidence of T2DM was 26.4/1000, 20.6/1000, and 21.9/1000 person-years for males, females, and overall, respectively. The adjusted HR for HTGW associated with T2DM was 7.63 (95% CI 4.32–13.49) for males and 7.75 (4.71–12.78) for females. Compared with consistent HTGW, with transformation from baseline HTGW to normal WC and normal triglycerides level at follow-up, the risk of developing T2DM was reduced by 75% and 78% for males and females. HTGW is a major risk factor for T2DM, but the risk could be reduced by improved triglycerides level and WC.Yongcheng RenYu LiuXizhuo SunKunpeng DengChongjian WangLinlin LiLu ZhangBingyuan WangYang ZhaoJunmei ZhouChengyi HanHongyan ZhangXiangyu YangXinping LuoChao PangLei YinTianping FengJingzhi ZhaoMing ZhangDongsheng HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yongcheng Ren Yu Liu Xizhuo Sun Kunpeng Deng Chongjian Wang Linlin Li Lu Zhang Bingyuan Wang Yang Zhao Junmei Zhou Chengyi Han Hongyan Zhang Xiangyu Yang Xinping Luo Chao Pang Lei Yin Tianping Feng Jingzhi Zhao Ming Zhang Dongsheng Hu Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study
description	Abstract Limited information is available on the effect of hypertriglyceridemia–waist (HTGW) combination and its dynamic status on the risk of type 2 diabetes mellitus (T2DM) in rural China. A cohort of 12,086 participants 18 to 92 years old was retained in this study. Kaplan-Meier analysis yielded the cumulative incidence of T2DM for each phenotype group (based on TG level and waist circumference [WC] at baseline). Cox regression yielded hazard ratios relating HTGW (based on TG level and WC at baseline and follow-up) to risk of developing T2DM. After a median follow-up of 6.0 years (71,432 person-years of follow-up), T2DM developed in 621 participants. For HTGW participants, the incidence of T2DM was 26.4/1000, 20.6/1000, and 21.9/1000 person-years for males, females, and overall, respectively. The adjusted HR for HTGW associated with T2DM was 7.63 (95% CI 4.32–13.49) for males and 7.75 (4.71–12.78) for females. Compared with consistent HTGW, with transformation from baseline HTGW to normal WC and normal triglycerides level at follow-up, the risk of developing T2DM was reduced by 75% and 78% for males and females. HTGW is a major risk factor for T2DM, but the risk could be reduced by improved triglycerides level and WC.
format	article
author	Yongcheng Ren Yu Liu Xizhuo Sun Kunpeng Deng Chongjian Wang Linlin Li Lu Zhang Bingyuan Wang Yang Zhao Junmei Zhou Chengyi Han Hongyan Zhang Xiangyu Yang Xinping Luo Chao Pang Lei Yin Tianping Feng Jingzhi Zhao Ming Zhang Dongsheng Hu
author_facet	Yongcheng Ren Yu Liu Xizhuo Sun Kunpeng Deng Chongjian Wang Linlin Li Lu Zhang Bingyuan Wang Yang Zhao Junmei Zhou Chengyi Han Hongyan Zhang Xiangyu Yang Xinping Luo Chao Pang Lei Yin Tianping Feng Jingzhi Zhao Ming Zhang Dongsheng Hu
author_sort	Yongcheng Ren
title	Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study
title_short	Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study
title_full	Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study
title_fullStr	Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study
title_full_unstemmed	Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study
title_sort	hypertriglyceridemia-waist and risk of developing type 2 diabetes: the rural chinese cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/50665be66df746a393c943bbfefabb6d
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Hypertriglyceridemia-waist and risk of developing type 2 diabetes: The Rural Chinese Cohort Study

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