The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review

Abstract Cognitive deficits are prominent features of the ultra-high risk state for psychosis that are known to impact functioning and course of illness. Cognitive remediation appears to be the most promising treatment approach to alleviate the cognitive deficits, which may translate into functional...

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Autores principales:	Louise Birkedal Glenthøj, Carsten Hjorthøj, Tina Dam Kristensen, Charlie Andrew Davidson, Merete Nordentoft
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/506dd8648f5b4590818a95b495507bf8
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spelling	oai:doaj.org-article:506dd8648f5b4590818a95b495507bf82021-12-02T16:19:59ZThe effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review10.1038/s41537-017-0021-92334-265Xhttps://doaj.org/article/506dd8648f5b4590818a95b495507bf82017-05-01T00:00:00Zhttps://doi.org/10.1038/s41537-017-0021-9https://doaj.org/toc/2334-265XAbstract Cognitive deficits are prominent features of the ultra-high risk state for psychosis that are known to impact functioning and course of illness. Cognitive remediation appears to be the most promising treatment approach to alleviate the cognitive deficits, which may translate into functional improvements. This study systematically reviewed the evidence on the effectiveness of cognitive remediation in the ultra-high risk population. The electronic databases MEDLINE, PsycINFO, and Embase were searched using keywords related to cognitive remediation and the UHR state. Studies were included if they were peer-reviewed, written in English, and included a population meeting standardized ultra-high risk criteria. Six original research articles were identified. All the studies provided computerized, bottom-up-based cognitive remediation, predominantly targeting neurocognitive function. Four out of five studies that reported a cognitive outcome found cognitive remediation to improve cognition in the domains of verbal memory, attention, and processing speed. Two out of four studies that reported on functional outcome found cognitive remediation to improve the functional outcome in the domains of social functioning and social adjustment. Zero out of the five studies that reported such an outcome found cognitive remediation to affect the magnitude of clinical symptoms. Research on the effect of cognitive remediation in the ultra-high risk state is still scarce. The current state of evidence indicates an effect of cognitive remediation on cognition and functioning in ultra-high risk individuals. More research on cognitive remediation in ultra-high risk is needed, notably in large-scale trials assessing the effect of neurocognitive and/or social cognitive remediation on multiple outcomes.Louise Birkedal GlenthøjCarsten HjorthøjTina Dam KristensenCharlie Andrew DavidsonMerete NordentoftNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 3, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Louise Birkedal Glenthøj Carsten Hjorthøj Tina Dam Kristensen Charlie Andrew Davidson Merete Nordentoft The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review
description	Abstract Cognitive deficits are prominent features of the ultra-high risk state for psychosis that are known to impact functioning and course of illness. Cognitive remediation appears to be the most promising treatment approach to alleviate the cognitive deficits, which may translate into functional improvements. This study systematically reviewed the evidence on the effectiveness of cognitive remediation in the ultra-high risk population. The electronic databases MEDLINE, PsycINFO, and Embase were searched using keywords related to cognitive remediation and the UHR state. Studies were included if they were peer-reviewed, written in English, and included a population meeting standardized ultra-high risk criteria. Six original research articles were identified. All the studies provided computerized, bottom-up-based cognitive remediation, predominantly targeting neurocognitive function. Four out of five studies that reported a cognitive outcome found cognitive remediation to improve cognition in the domains of verbal memory, attention, and processing speed. Two out of four studies that reported on functional outcome found cognitive remediation to improve the functional outcome in the domains of social functioning and social adjustment. Zero out of the five studies that reported such an outcome found cognitive remediation to affect the magnitude of clinical symptoms. Research on the effect of cognitive remediation in the ultra-high risk state is still scarce. The current state of evidence indicates an effect of cognitive remediation on cognition and functioning in ultra-high risk individuals. More research on cognitive remediation in ultra-high risk is needed, notably in large-scale trials assessing the effect of neurocognitive and/or social cognitive remediation on multiple outcomes.
format	article
author	Louise Birkedal Glenthøj Carsten Hjorthøj Tina Dam Kristensen Charlie Andrew Davidson Merete Nordentoft
author_facet	Louise Birkedal Glenthøj Carsten Hjorthøj Tina Dam Kristensen Charlie Andrew Davidson Merete Nordentoft
author_sort	Louise Birkedal Glenthøj
title	The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review
title_short	The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review
title_full	The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review
title_fullStr	The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review
title_full_unstemmed	The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review
title_sort	effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/506dd8648f5b4590818a95b495507bf8
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The effect of cognitive remediation in individuals at ultra-high risk for psychosis: a systematic review

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