Actuation enhances patterning in human neural tube organoids

Mechanical forces, along with gene regulatory networks and cell-cell signalling, play an important role in the complex organization of tissues. Here the authors describe devices that actively apply mechanical force to developing neural tube, demonstrating that mechanical forces increase growth and e...

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Autores principales:	Abdel Rahman Abdel Fattah, Brian Daza, Gregorius Rustandi, Miguel Ángel Berrocal-Rubio, Benjamin Gorissen, Suresh Poovathingal, Kristofer Davie, Jorge Barrasa-Fano, Mar Cóndor, Xuanye Cao, Derek Hadar Rosenzweig, Yunping Lei, Richard Finnell, Catherine Verfaillie, Maurilio Sampaolesi, Peter Dedecker, Hans Van Oosterwyck, Stein Aerts, Adrian Ranga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/506e1172f48248a2922027f6f24d172b
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spelling	oai:doaj.org-article:506e1172f48248a2922027f6f24d172b2021-12-02T16:52:57ZActuation enhances patterning in human neural tube organoids10.1038/s41467-021-22952-02041-1723https://doaj.org/article/506e1172f48248a2922027f6f24d172b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22952-0https://doaj.org/toc/2041-1723Mechanical forces, along with gene regulatory networks and cell-cell signalling, play an important role in the complex organization of tissues. Here the authors describe devices that actively apply mechanical force to developing neural tube, demonstrating that mechanical forces increase growth and enhance patterning.Abdel Rahman Abdel FattahBrian DazaGregorius RustandiMiguel Ángel Berrocal-RubioBenjamin GorissenSuresh PoovathingalKristofer DavieJorge Barrasa-FanoMar CóndorXuanye CaoDerek Hadar RosenzweigYunping LeiRichard FinnellCatherine VerfaillieMaurilio SampaolesiPeter DedeckerHans Van OosterwyckStein AertsAdrian RangaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abdel Rahman Abdel Fattah Brian Daza Gregorius Rustandi Miguel Ángel Berrocal-Rubio Benjamin Gorissen Suresh Poovathingal Kristofer Davie Jorge Barrasa-Fano Mar Cóndor Xuanye Cao Derek Hadar Rosenzweig Yunping Lei Richard Finnell Catherine Verfaillie Maurilio Sampaolesi Peter Dedecker Hans Van Oosterwyck Stein Aerts Adrian Ranga Actuation enhances patterning in human neural tube organoids
description	Mechanical forces, along with gene regulatory networks and cell-cell signalling, play an important role in the complex organization of tissues. Here the authors describe devices that actively apply mechanical force to developing neural tube, demonstrating that mechanical forces increase growth and enhance patterning.
format	article
author	Abdel Rahman Abdel Fattah Brian Daza Gregorius Rustandi Miguel Ángel Berrocal-Rubio Benjamin Gorissen Suresh Poovathingal Kristofer Davie Jorge Barrasa-Fano Mar Cóndor Xuanye Cao Derek Hadar Rosenzweig Yunping Lei Richard Finnell Catherine Verfaillie Maurilio Sampaolesi Peter Dedecker Hans Van Oosterwyck Stein Aerts Adrian Ranga
author_facet	Abdel Rahman Abdel Fattah Brian Daza Gregorius Rustandi Miguel Ángel Berrocal-Rubio Benjamin Gorissen Suresh Poovathingal Kristofer Davie Jorge Barrasa-Fano Mar Cóndor Xuanye Cao Derek Hadar Rosenzweig Yunping Lei Richard Finnell Catherine Verfaillie Maurilio Sampaolesi Peter Dedecker Hans Van Oosterwyck Stein Aerts Adrian Ranga
author_sort	Abdel Rahman Abdel Fattah
title	Actuation enhances patterning in human neural tube organoids
title_short	Actuation enhances patterning in human neural tube organoids
title_full	Actuation enhances patterning in human neural tube organoids
title_fullStr	Actuation enhances patterning in human neural tube organoids
title_full_unstemmed	Actuation enhances patterning in human neural tube organoids
title_sort	actuation enhances patterning in human neural tube organoids
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/506e1172f48248a2922027f6f24d172b
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Actuation enhances patterning in human neural tube organoids

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