The effect of dietary lipid quality in early life on serum LysoPC(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats

Abstract Being born small-for-gestational-age, especially with subsequent catch-up growth, is associated with impaired metabolic health in later-life. We previously showed that a postnatal diet with an adapted lipid droplet structure can ameliorate some of the adverse metabolic consequences in intra...

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Autores principales:	Andrea Kodde, Mona Mischke, Maryam Rakhshandehroo, Jenny Voggel, Gregor Fink, Eva Nüsken, Manfred Rauh, Eline M. van der Beek, Jörg Dötsch, Kai-Dietrich Nüsken
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Metabolomics Lysophosphatidylcholine Intrauterine growth restriction Postnatal diet Blood glucose Diabetes susceptibility Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/506ebc937f4d48bda0048590b423d155
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spelling	oai:doaj.org-article:506ebc937f4d48bda0048590b423d1552021-11-28T12:13:37ZThe effect of dietary lipid quality in early life on serum LysoPC(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats10.1186/s12986-021-00614-81743-7075https://doaj.org/article/506ebc937f4d48bda0048590b423d1552021-11-01T00:00:00Zhttps://doi.org/10.1186/s12986-021-00614-8https://doaj.org/toc/1743-7075Abstract Being born small-for-gestational-age, especially with subsequent catch-up growth, is associated with impaired metabolic health in later-life. We previously showed that a postnatal diet with an adapted lipid droplet structure can ameliorate some of the adverse metabolic consequences in intrauterine growth-restricted (IUGR) rats. The aim of the present work was to explore possible underlying mechanism(s) and potential biomarkers. To this end, serum metabolomics was performed in postnatal day (PN) 42 and PN96 samples of the above-mentioned rat offspring, born after uterine vasculature ligation. Blood samples were collected at PN42, directly after a postnatal dietary intervention with either complex lipid matrix (CLM) or control (CTRL) diet, and at PN96 after a subsequent western-style diet (WSD). Offspring of Non-operated (NOP) dams fed CTRL in early life were included as control group. In the PN42 metabolomics data, 11 co-abundance modules of metabolites were identified, of which four were significantly correlated to adult blood glucose levels at PN96. Further analyses showed that Lysophosphatidylcholine(18:2) (LysoPC(18:2)) levels were reduced by ligation (p < 0.01) and restored in CLM fed animals (p < 0.05). LysoPC(18:2) levels at PN42 correlated inversely with adult blood glucose levels. These data indicate that early-life LysoPC(18:2) blood levels may predict adult blood glucose levels and are affected by a postnatal diet with an adapted lipid droplet structure in IUGR offspring.Andrea KoddeMona MischkeMaryam RakhshandehrooJenny VoggelGregor FinkEva NüskenManfred RauhEline M. van der BeekJörg DötschKai-Dietrich NüskenBMCarticleMetabolomicsLysophosphatidylcholineIntrauterine growth restrictionPostnatal dietBlood glucoseDiabetes susceptibilityNutrition. Foods and food supplyTX341-641Nutritional diseases. Deficiency diseasesRC620-627ENNutrition & Metabolism, Vol 18, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Metabolomics Lysophosphatidylcholine Intrauterine growth restriction Postnatal diet Blood glucose Diabetes susceptibility Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Metabolomics Lysophosphatidylcholine Intrauterine growth restriction Postnatal diet Blood glucose Diabetes susceptibility Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627 Andrea Kodde Mona Mischke Maryam Rakhshandehroo Jenny Voggel Gregor Fink Eva Nüsken Manfred Rauh Eline M. van der Beek Jörg Dötsch Kai-Dietrich Nüsken The effect of dietary lipid quality in early life on serum LysoPC(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats
description	Abstract Being born small-for-gestational-age, especially with subsequent catch-up growth, is associated with impaired metabolic health in later-life. We previously showed that a postnatal diet with an adapted lipid droplet structure can ameliorate some of the adverse metabolic consequences in intrauterine growth-restricted (IUGR) rats. The aim of the present work was to explore possible underlying mechanism(s) and potential biomarkers. To this end, serum metabolomics was performed in postnatal day (PN) 42 and PN96 samples of the above-mentioned rat offspring, born after uterine vasculature ligation. Blood samples were collected at PN42, directly after a postnatal dietary intervention with either complex lipid matrix (CLM) or control (CTRL) diet, and at PN96 after a subsequent western-style diet (WSD). Offspring of Non-operated (NOP) dams fed CTRL in early life were included as control group. In the PN42 metabolomics data, 11 co-abundance modules of metabolites were identified, of which four were significantly correlated to adult blood glucose levels at PN96. Further analyses showed that Lysophosphatidylcholine(18:2) (LysoPC(18:2)) levels were reduced by ligation (p < 0.01) and restored in CLM fed animals (p < 0.05). LysoPC(18:2) levels at PN42 correlated inversely with adult blood glucose levels. These data indicate that early-life LysoPC(18:2) blood levels may predict adult blood glucose levels and are affected by a postnatal diet with an adapted lipid droplet structure in IUGR offspring.
format	article
author	Andrea Kodde Mona Mischke Maryam Rakhshandehroo Jenny Voggel Gregor Fink Eva Nüsken Manfred Rauh Eline M. van der Beek Jörg Dötsch Kai-Dietrich Nüsken
author_facet	Andrea Kodde Mona Mischke Maryam Rakhshandehroo Jenny Voggel Gregor Fink Eva Nüsken Manfred Rauh Eline M. van der Beek Jörg Dötsch Kai-Dietrich Nüsken
author_sort	Andrea Kodde
title	The effect of dietary lipid quality in early life on serum LysoPC(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats
title_short	The effect of dietary lipid quality in early life on serum LysoPC(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats
title_full	The effect of dietary lipid quality in early life on serum LysoPC(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats
title_fullStr	The effect of dietary lipid quality in early life on serum LysoPC(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats
title_full_unstemmed	The effect of dietary lipid quality in early life on serum LysoPC(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats
title_sort	effect of dietary lipid quality in early life on serum lysopc(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats
publisher	BMC
publishDate	2021
url	https://doaj.org/article/506ebc937f4d48bda0048590b423d155
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The effect of dietary lipid quality in early life on serum LysoPC(18:2) levels and their association with adult blood glucose levels in intrauterine growth restricted rats

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