2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions

The gem-difluoroalkene functionality is relevant to drug design as it is a bioisostere of a carbonyl group. Here, the authors report the synthesis of 2,2-difluorovinyl benzoates as versatile building blocks for modular synthesis of gem-difluoroenol ethers and gem-difluoroalkenes by nickel-catalyzed...

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Autores principales:	Bingnan Du, Chun-Ming Chan, Pui-Yiu Lee, Leong-Hung Cheung, Xin Xu, Zhenyang Lin, Wing-Yiu Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5070c81d1d4a464c9f37132bc268c200
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spelling	oai:doaj.org-article:5070c81d1d4a464c9f37132bc268c2002021-12-02T14:09:00Z2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions10.1038/s41467-020-20725-92041-1723https://doaj.org/article/5070c81d1d4a464c9f37132bc268c2002021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20725-9https://doaj.org/toc/2041-1723The gem-difluoroalkene functionality is relevant to drug design as it is a bioisostere of a carbonyl group. Here, the authors report the synthesis of 2,2-difluorovinyl benzoates as versatile building blocks for modular synthesis of gem-difluoroenol ethers and gem-difluoroalkenes by nickel-catalyzed cross coupling.Bingnan DuChun-Ming ChanPui-Yiu LeeLeong-Hung CheungXin XuZhenyang LinWing-Yiu YuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bingnan Du Chun-Ming Chan Pui-Yiu Lee Leong-Hung Cheung Xin Xu Zhenyang Lin Wing-Yiu Yu 2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions
description	The gem-difluoroalkene functionality is relevant to drug design as it is a bioisostere of a carbonyl group. Here, the authors report the synthesis of 2,2-difluorovinyl benzoates as versatile building blocks for modular synthesis of gem-difluoroenol ethers and gem-difluoroalkenes by nickel-catalyzed cross coupling.
format	article
author	Bingnan Du Chun-Ming Chan Pui-Yiu Lee Leong-Hung Cheung Xin Xu Zhenyang Lin Wing-Yiu Yu
author_facet	Bingnan Du Chun-Ming Chan Pui-Yiu Lee Leong-Hung Cheung Xin Xu Zhenyang Lin Wing-Yiu Yu
author_sort	Bingnan Du
title	2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions
title_short	2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions
title_full	2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions
title_fullStr	2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions
title_full_unstemmed	2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions
title_sort	2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by ni-catalyzed cross-coupling reactions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5070c81d1d4a464c9f37132bc268c200
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2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions

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