Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

How cancer-associated fibroblasts become activated to support metastasis is not well understood. Here, Avgustinova et al. show that tumour cell-derived Wnt7a activates TGFβ signaling in fibroblasts, inducing them to remodel the microenvironment to the state, which promotes tumour invasiveness and me...

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Autores principales:	Alexandra Avgustinova, Marjan Iravani, David Robertson, Antony Fearns, Qiong Gao, Pamela Klingbeil, Andrew M. Hanby, Valerie Speirs, Erik Sahai, Fernando Calvo, Clare M. Isacke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50718db53f024eee88e49a2037310de2
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spelling	oai:doaj.org-article:50718db53f024eee88e49a2037310de22021-12-02T17:32:08ZTumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness10.1038/ncomms103052041-1723https://doaj.org/article/50718db53f024eee88e49a2037310de22016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10305https://doaj.org/toc/2041-1723How cancer-associated fibroblasts become activated to support metastasis is not well understood. Here, Avgustinova et al. show that tumour cell-derived Wnt7a activates TGFβ signaling in fibroblasts, inducing them to remodel the microenvironment to the state, which promotes tumour invasiveness and metastasis.Alexandra AvgustinovaMarjan IravaniDavid RobertsonAntony FearnsQiong GaoPamela KlingbeilAndrew M. HanbyValerie SpeirsErik SahaiFernando CalvoClare M. IsackeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexandra Avgustinova Marjan Iravani David Robertson Antony Fearns Qiong Gao Pamela Klingbeil Andrew M. Hanby Valerie Speirs Erik Sahai Fernando Calvo Clare M. Isacke Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
description	How cancer-associated fibroblasts become activated to support metastasis is not well understood. Here, Avgustinova et al. show that tumour cell-derived Wnt7a activates TGFβ signaling in fibroblasts, inducing them to remodel the microenvironment to the state, which promotes tumour invasiveness and metastasis.
format	article
author	Alexandra Avgustinova Marjan Iravani David Robertson Antony Fearns Qiong Gao Pamela Klingbeil Andrew M. Hanby Valerie Speirs Erik Sahai Fernando Calvo Clare M. Isacke
author_facet	Alexandra Avgustinova Marjan Iravani David Robertson Antony Fearns Qiong Gao Pamela Klingbeil Andrew M. Hanby Valerie Speirs Erik Sahai Fernando Calvo Clare M. Isacke
author_sort	Alexandra Avgustinova
title	Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
title_short	Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
title_full	Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
title_fullStr	Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
title_full_unstemmed	Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
title_sort	tumour cell-derived wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/50718db53f024eee88e49a2037310de2
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Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

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