Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study

Abstract Coronavirus disease 2019 (COVID-19) is a pandemic viral disease affecting also obstetric patients and uncertainties exist about the prognostic role of inflammatory biomarkers and hemocytometry values in patients with this infection. To clarify that, we have assessed the values of several in...

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Autores principales:	Andrea Lombardi, Silvia Duiella, Letizia Li Piani, Agnese Comelli, Ferruccio Ceriotti, Massimo Oggioni, Antonio Muscatello, Alessandra Bandera, Andrea Gori, Enrico Ferrazzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5072000495b0482d9ce6107c7e1a9086
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spelling	oai:doaj.org-article:5072000495b0482d9ce6107c7e1a90862021-12-02T17:45:02ZInflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study10.1038/s41598-021-92885-72045-2322https://doaj.org/article/5072000495b0482d9ce6107c7e1a90862021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92885-7https://doaj.org/toc/2045-2322Abstract Coronavirus disease 2019 (COVID-19) is a pandemic viral disease affecting also obstetric patients and uncertainties exist about the prognostic role of inflammatory biomarkers and hemocytometry values in patients with this infection. To clarify that, we have assessed the values of several inflammatory biomarkers and hemocytometry variables in a cohort of obstetric patients hospitalized with COVID-19 and we have correlated the values at admission with the need of oxygen supplementation during the hospitalization. Overall, among 62 (27.3%) pregnant women and 165 (72.7%) postpartum women, 21 (9.2%) patients received oxygen supplementation and 2 (0.9%) required admission to intensive care unit but none died. During hospitalization leukocytes (p < 0.001), neutrophils (p < 0.001), neutrophils to lymphocytes ratio (p < 0.001) and C reactive protein (p < 0.001) decreased significantly, whereas lymphocytes (p < 0.001), platelets (p < 0.001) and ferritin (p = 0.001) increased. Lymphocyte values at admission were correlated with oxygen need, with a 26% higher risk of oxygen supplementation for each 1000 cells decreases. Overall, in obstetric patients hospitalized with COVID-19, C reactive protein is the inflammatory biomarker that better mirrors the course of the disease whereas D-dimer or ferritin are not reliable predictors of poor outcome. Care to the need of oxygen supplementation should be reserved to patients with reduced lymphocyte values at admission.Andrea LombardiSilvia DuiellaLetizia Li PianiAgnese ComelliFerruccio CeriottiMassimo OggioniAntonio MuscatelloAlessandra BanderaAndrea GoriEnrico FerrazziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrea Lombardi Silvia Duiella Letizia Li Piani Agnese Comelli Ferruccio Ceriotti Massimo Oggioni Antonio Muscatello Alessandra Bandera Andrea Gori Enrico Ferrazzi Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
description	Abstract Coronavirus disease 2019 (COVID-19) is a pandemic viral disease affecting also obstetric patients and uncertainties exist about the prognostic role of inflammatory biomarkers and hemocytometry values in patients with this infection. To clarify that, we have assessed the values of several inflammatory biomarkers and hemocytometry variables in a cohort of obstetric patients hospitalized with COVID-19 and we have correlated the values at admission with the need of oxygen supplementation during the hospitalization. Overall, among 62 (27.3%) pregnant women and 165 (72.7%) postpartum women, 21 (9.2%) patients received oxygen supplementation and 2 (0.9%) required admission to intensive care unit but none died. During hospitalization leukocytes (p < 0.001), neutrophils (p < 0.001), neutrophils to lymphocytes ratio (p < 0.001) and C reactive protein (p < 0.001) decreased significantly, whereas lymphocytes (p < 0.001), platelets (p < 0.001) and ferritin (p = 0.001) increased. Lymphocyte values at admission were correlated with oxygen need, with a 26% higher risk of oxygen supplementation for each 1000 cells decreases. Overall, in obstetric patients hospitalized with COVID-19, C reactive protein is the inflammatory biomarker that better mirrors the course of the disease whereas D-dimer or ferritin are not reliable predictors of poor outcome. Care to the need of oxygen supplementation should be reserved to patients with reduced lymphocyte values at admission.
format	article
author	Andrea Lombardi Silvia Duiella Letizia Li Piani Agnese Comelli Ferruccio Ceriotti Massimo Oggioni Antonio Muscatello Alessandra Bandera Andrea Gori Enrico Ferrazzi
author_facet	Andrea Lombardi Silvia Duiella Letizia Li Piani Agnese Comelli Ferruccio Ceriotti Massimo Oggioni Antonio Muscatello Alessandra Bandera Andrea Gori Enrico Ferrazzi
author_sort	Andrea Lombardi
title	Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title_short	Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title_full	Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title_fullStr	Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title_full_unstemmed	Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study
title_sort	inflammatory biomarkers in pregnant women with covid-19: a retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5072000495b0482d9ce6107c7e1a9086
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Inflammatory biomarkers in pregnant women with COVID-19: a retrospective cohort study

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