Screening of oral squamous cell carcinoma by serum changes: A systematic review and meta-analysis

Background: Oral squamous cell carcinoma (OSCC) is the sixth common cancer in the world and 90% of oral malignant tumors. The aim of this study was the investigation of changes in some metabolic elements of OSCC patients' serum.Materials and Methods: In this study, international databases such...

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Autores principales:	Forooz Keshani, Saeedeh Khalesi, Alireza Aghaz, Mohammadreza Farhang, Nabiollah Akbari
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	elements meta-analysis mouth neoplasms serum squamous cell carcinoma Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/5074ecba378a41b79535718a67d4ce4f
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spelling	oai:doaj.org-article:5074ecba378a41b79535718a67d4ce4f2021-11-12T10:10:18ZScreening of oral squamous cell carcinoma by serum changes: A systematic review and meta-analysis1735-33272008-025510.4103/1735-3327.328756https://doaj.org/article/5074ecba378a41b79535718a67d4ce4f2021-01-01T00:00:00Zhttp://www.drjjournal.net/article.asp?issn=1735-3327;year=2021;volume=18;issue=1;spage=88;epage=88;aulast=Keshanihttps://doaj.org/toc/1735-3327https://doaj.org/toc/2008-0255Background: Oral squamous cell carcinoma (OSCC) is the sixth common cancer in the world and 90% of oral malignant tumors. The aim of this study was the investigation of changes in some metabolic elements of OSCC patients' serum.Materials and Methods: In this study, international databases such as PubMed, Science Direct, Scopus, Web of Science, and National (Magiran, IranMedex) were searched from 1980 to 2019. To analyze the data, a random-effects model was used to combine the differences in the mean of studies in STATA Software (version 12).Results: A total of 724 articles were found with initial searching that 474 duplicate articles, 228 articles were excluded by reviewing the title and abstracts, and 17 articles were excluded from the study due to lack of inclusion criteria. Finally, five articles entered the meta-analysis phase. The mean difference value for zinc concentration of blood serum was 2.01 (95% confidence interval (CI): 0.36–3.66) and for copper was 1.04 (95% CI: 0.01–2.07). In both populations, the heterogeneity was found between studies (I 2 = 97.4, P < 0.001).Conclusion: Probably higher serum levels of copper and zinc could be one way to help to do a primary screening of OSCC in suspected patients.Forooz KeshaniSaeedeh KhalesiAlireza AghazMohammadreza FarhangNabiollah AkbariWolters Kluwer Medknow Publicationsarticleelementsmeta-analysismouth neoplasmsserumsquamous cell carcinomaDentistryRK1-715ENDental Research Journal, Vol 18, Iss 1, Pp 88-88 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	elements meta-analysis mouth neoplasms serum squamous cell carcinoma Dentistry RK1-715
spellingShingle	elements meta-analysis mouth neoplasms serum squamous cell carcinoma Dentistry RK1-715 Forooz Keshani Saeedeh Khalesi Alireza Aghaz Mohammadreza Farhang Nabiollah Akbari Screening of oral squamous cell carcinoma by serum changes: A systematic review and meta-analysis
description	Background: Oral squamous cell carcinoma (OSCC) is the sixth common cancer in the world and 90% of oral malignant tumors. The aim of this study was the investigation of changes in some metabolic elements of OSCC patients' serum.Materials and Methods: In this study, international databases such as PubMed, Science Direct, Scopus, Web of Science, and National (Magiran, IranMedex) were searched from 1980 to 2019. To analyze the data, a random-effects model was used to combine the differences in the mean of studies in STATA Software (version 12).Results: A total of 724 articles were found with initial searching that 474 duplicate articles, 228 articles were excluded by reviewing the title and abstracts, and 17 articles were excluded from the study due to lack of inclusion criteria. Finally, five articles entered the meta-analysis phase. The mean difference value for zinc concentration of blood serum was 2.01 (95% confidence interval (CI): 0.36–3.66) and for copper was 1.04 (95% CI: 0.01–2.07). In both populations, the heterogeneity was found between studies (I 2 = 97.4, P < 0.001).Conclusion: Probably higher serum levels of copper and zinc could be one way to help to do a primary screening of OSCC in suspected patients.
format	article
author	Forooz Keshani Saeedeh Khalesi Alireza Aghaz Mohammadreza Farhang Nabiollah Akbari
author_facet	Forooz Keshani Saeedeh Khalesi Alireza Aghaz Mohammadreza Farhang Nabiollah Akbari
author_sort	Forooz Keshani
title	Screening of oral squamous cell carcinoma by serum changes: A systematic review and meta-analysis
title_short	Screening of oral squamous cell carcinoma by serum changes: A systematic review and meta-analysis
title_full	Screening of oral squamous cell carcinoma by serum changes: A systematic review and meta-analysis
title_fullStr	Screening of oral squamous cell carcinoma by serum changes: A systematic review and meta-analysis
title_full_unstemmed	Screening of oral squamous cell carcinoma by serum changes: A systematic review and meta-analysis
title_sort	screening of oral squamous cell carcinoma by serum changes: a systematic review and meta-analysis
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/5074ecba378a41b79535718a67d4ce4f
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Screening of oral squamous cell carcinoma by serum changes: A systematic review and meta-analysis

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