Pupal cannibalism by worker honey bees contributes to the spread of deformed wing virus

Abstract Transmission routes impact pathogen virulence and genetics, therefore comprehensive knowledge of these routes and their contribution to pathogen circulation is essential for understanding host–pathogen interactions and designing control strategies. Deformed wing virus (DWV), a principal vir...

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Autores principales:	Francisco Posada-Florez, Zachary S. Lamas, David J. Hawthorne, Yanping Chen, Jay D. Evans, Eugene V. Ryabov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/507adb6d993a4995be19a01e334a88cd
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spelling	oai:doaj.org-article:507adb6d993a4995be19a01e334a88cd2021-12-02T16:56:02ZPupal cannibalism by worker honey bees contributes to the spread of deformed wing virus10.1038/s41598-021-88649-y2045-2322https://doaj.org/article/507adb6d993a4995be19a01e334a88cd2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88649-yhttps://doaj.org/toc/2045-2322Abstract Transmission routes impact pathogen virulence and genetics, therefore comprehensive knowledge of these routes and their contribution to pathogen circulation is essential for understanding host–pathogen interactions and designing control strategies. Deformed wing virus (DWV), a principal viral pathogen of honey bees associated with increased honey bee mortality and colony losses, became highly virulent with the spread of its vector, the ectoparasitic mite Varroa destructor. Reproduction of Varroa mites occurs in capped brood cells and mite-infested pupae from these cells usually have high levels of DWV. The removal of mite-infested pupae by worker bees, Varroa Sensitive Hygiene (VSH), leads to cannibalization of pupae with high DWV loads, thereby offering an alternative route for virus transmission. We used genetically tagged DWV to investigate virus transmission to and between worker bees following pupal cannibalisation under experimental conditions. We demonstrated that cannibalization of DWV-infected pupae resulted in high levels of this virus in worker bees and that the acquired virus was then transmitted between bees via trophallaxis, allowing circulation of Varroa-vectored DWV variants without the mites. Despite the known benefits of hygienic behaviour, it is possible that higher levels of VSH activity may result in increased transmission of DWV via cannibalism and trophallaxis.Francisco Posada-FlorezZachary S. LamasDavid J. HawthorneYanping ChenJay D. EvansEugene V. RyabovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francisco Posada-Florez Zachary S. Lamas David J. Hawthorne Yanping Chen Jay D. Evans Eugene V. Ryabov Pupal cannibalism by worker honey bees contributes to the spread of deformed wing virus
description	Abstract Transmission routes impact pathogen virulence and genetics, therefore comprehensive knowledge of these routes and their contribution to pathogen circulation is essential for understanding host–pathogen interactions and designing control strategies. Deformed wing virus (DWV), a principal viral pathogen of honey bees associated with increased honey bee mortality and colony losses, became highly virulent with the spread of its vector, the ectoparasitic mite Varroa destructor. Reproduction of Varroa mites occurs in capped brood cells and mite-infested pupae from these cells usually have high levels of DWV. The removal of mite-infested pupae by worker bees, Varroa Sensitive Hygiene (VSH), leads to cannibalization of pupae with high DWV loads, thereby offering an alternative route for virus transmission. We used genetically tagged DWV to investigate virus transmission to and between worker bees following pupal cannibalisation under experimental conditions. We demonstrated that cannibalization of DWV-infected pupae resulted in high levels of this virus in worker bees and that the acquired virus was then transmitted between bees via trophallaxis, allowing circulation of Varroa-vectored DWV variants without the mites. Despite the known benefits of hygienic behaviour, it is possible that higher levels of VSH activity may result in increased transmission of DWV via cannibalism and trophallaxis.
format	article
author	Francisco Posada-Florez Zachary S. Lamas David J. Hawthorne Yanping Chen Jay D. Evans Eugene V. Ryabov
author_facet	Francisco Posada-Florez Zachary S. Lamas David J. Hawthorne Yanping Chen Jay D. Evans Eugene V. Ryabov
author_sort	Francisco Posada-Florez
title	Pupal cannibalism by worker honey bees contributes to the spread of deformed wing virus
title_short	Pupal cannibalism by worker honey bees contributes to the spread of deformed wing virus
title_full	Pupal cannibalism by worker honey bees contributes to the spread of deformed wing virus
title_fullStr	Pupal cannibalism by worker honey bees contributes to the spread of deformed wing virus
title_full_unstemmed	Pupal cannibalism by worker honey bees contributes to the spread of deformed wing virus
title_sort	pupal cannibalism by worker honey bees contributes to the spread of deformed wing virus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/507adb6d993a4995be19a01e334a88cd
work_keys_str_mv	AT franciscoposadaflorez pupalcannibalismbyworkerhoneybeescontributestothespreadofdeformedwingvirus AT zacharyslamas pupalcannibalismbyworkerhoneybeescontributestothespreadofdeformedwingvirus AT davidjhawthorne pupalcannibalismbyworkerhoneybeescontributestothespreadofdeformedwingvirus AT yanpingchen pupalcannibalismbyworkerhoneybeescontributestothespreadofdeformedwingvirus AT jaydevans pupalcannibalismbyworkerhoneybeescontributestothespreadofdeformedwingvirus AT eugenevryabov pupalcannibalismbyworkerhoneybeescontributestothespreadofdeformedwingvirus
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Pupal cannibalism by worker honey bees contributes to the spread of deformed wing virus

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