HIV induces airway basal progenitor cells to adopt an inflammatory phenotype

Abstract Despite the introduction of anti-retroviral therapy, chronic HIV infection is associated with an increased incidence of other comorbidities such as COPD. Based on the knowledge that binding of HIV to human airway basal stem/progenitor cells (BC) induces a destructive phenotype by increased...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nancy P. Y. Chung, K. M. Faisal Khan, Robert J. Kaner, Sarah L. O’Beirne, Ronald G. Crystal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5084a3a5429d4adeaf31eaaa1970d4a3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5084a3a5429d4adeaf31eaaa1970d4a3
record_format	dspace
spelling	oai:doaj.org-article:5084a3a5429d4adeaf31eaaa1970d4a32021-12-02T12:11:52ZHIV induces airway basal progenitor cells to adopt an inflammatory phenotype10.1038/s41598-021-82143-12045-2322https://doaj.org/article/5084a3a5429d4adeaf31eaaa1970d4a32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82143-1https://doaj.org/toc/2045-2322Abstract Despite the introduction of anti-retroviral therapy, chronic HIV infection is associated with an increased incidence of other comorbidities such as COPD. Based on the knowledge that binding of HIV to human airway basal stem/progenitor cells (BC) induces a destructive phenotype by increased MMP-9 expression through MAPK signaling pathways, we hypothesized that HIV induces the BC to express inflammatory mediators that contribute to the pathogenesis of emphysema. Our data demonstrate that airway BC isolated from HAART-treated HIV+ nonsmokers spontaneously release inflammatory mediators IL-8, IL-1β, ICAM-1 and GM-CSF. Similarly, exposure of normal BC to HIV in vitro up-regulates expression of the same inflammatory mediators. These HIV-BC derived mediators induce migration of alveolar macrophages (AM) and neutrophils and stimulate AM proliferation. This HIV-induced inflammatory phenotype likely contributes to lung inflammation in HIV+ individuals and provides explanation for the increased incidence of COPD in HIV+ individuals.Nancy P. Y. ChungK. M. Faisal KhanRobert J. KanerSarah L. O’BeirneRonald G. CrystalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nancy P. Y. Chung K. M. Faisal Khan Robert J. Kaner Sarah L. O’Beirne Ronald G. Crystal HIV induces airway basal progenitor cells to adopt an inflammatory phenotype
description	Abstract Despite the introduction of anti-retroviral therapy, chronic HIV infection is associated with an increased incidence of other comorbidities such as COPD. Based on the knowledge that binding of HIV to human airway basal stem/progenitor cells (BC) induces a destructive phenotype by increased MMP-9 expression through MAPK signaling pathways, we hypothesized that HIV induces the BC to express inflammatory mediators that contribute to the pathogenesis of emphysema. Our data demonstrate that airway BC isolated from HAART-treated HIV+ nonsmokers spontaneously release inflammatory mediators IL-8, IL-1β, ICAM-1 and GM-CSF. Similarly, exposure of normal BC to HIV in vitro up-regulates expression of the same inflammatory mediators. These HIV-BC derived mediators induce migration of alveolar macrophages (AM) and neutrophils and stimulate AM proliferation. This HIV-induced inflammatory phenotype likely contributes to lung inflammation in HIV+ individuals and provides explanation for the increased incidence of COPD in HIV+ individuals.
format	article
author	Nancy P. Y. Chung K. M. Faisal Khan Robert J. Kaner Sarah L. O’Beirne Ronald G. Crystal
author_facet	Nancy P. Y. Chung K. M. Faisal Khan Robert J. Kaner Sarah L. O’Beirne Ronald G. Crystal
author_sort	Nancy P. Y. Chung
title	HIV induces airway basal progenitor cells to adopt an inflammatory phenotype
title_short	HIV induces airway basal progenitor cells to adopt an inflammatory phenotype
title_full	HIV induces airway basal progenitor cells to adopt an inflammatory phenotype
title_fullStr	HIV induces airway basal progenitor cells to adopt an inflammatory phenotype
title_full_unstemmed	HIV induces airway basal progenitor cells to adopt an inflammatory phenotype
title_sort	hiv induces airway basal progenitor cells to adopt an inflammatory phenotype
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5084a3a5429d4adeaf31eaaa1970d4a3
work_keys_str_mv	AT nancypychung hivinducesairwaybasalprogenitorcellstoadoptaninflammatoryphenotype AT kmfaisalkhan hivinducesairwaybasalprogenitorcellstoadoptaninflammatoryphenotype AT robertjkaner hivinducesairwaybasalprogenitorcellstoadoptaninflammatoryphenotype AT sarahlobeirne hivinducesairwaybasalprogenitorcellstoadoptaninflammatoryphenotype AT ronaldgcrystal hivinducesairwaybasalprogenitorcellstoadoptaninflammatoryphenotype
_version_	1718394573009453056

HIV induces airway basal progenitor cells to adopt an inflammatory phenotype

Ejemplares similares