Pathophysiological role of major adipokines in Atrial Fibrillation

Abstract Background The adipokines, secreted from adipose tissue or body fats, are also called adipocytokines which are cytokines, cell signaling proteins or cell–cell communication. However, AF is a common cardiac arrhythmia in which the heart beats so fast by abnormal beating and is a serious publ...

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Autores principales:	Saira Rafaqat, Sana Rafaqat, Simon Rafaqat
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Adiponectin Apelin C1q/TNF-Related Protein 3 Chemerin Omentin-1 Interleukin-6 Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/508ba2fa3d7d497eb75f72108b328daf
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spelling	oai:doaj.org-article:508ba2fa3d7d497eb75f72108b328daf2021-11-08T11:04:24ZPathophysiological role of major adipokines in Atrial Fibrillation10.1186/s42444-021-00048-62466-1171https://doaj.org/article/508ba2fa3d7d497eb75f72108b328daf2021-11-01T00:00:00Zhttps://doi.org/10.1186/s42444-021-00048-6https://doaj.org/toc/2466-1171Abstract Background The adipokines, secreted from adipose tissue or body fats, are also called adipocytokines which are cytokines, cell signaling proteins or cell–cell communication. However, AF is a common cardiac arrhythmia in which the heart beats so fast by abnormal beating and is a serious public health disease associated with increased heart failure, systemic thromboembolism, and death. Adipokines are cardiovascular disease (CVD) mediators or biomarkers that affect the heart as well as blood vessels, by increasing the cardiac contractility and action potential duration, which result in the extent of left ventricular and atrial remodeling. Main body Google Scholar, PubMed, and science direct were used to review the literature. Many keywords were used for searching the literature such as Adipokines, Leptin, Apelin, Adiponectin, Omentin-1, Chemerin, CTRP3, TNF-α, IL-6, IL-10, and AF. According to the literature, much more data are available for numerous adipokines, but this review article only has taken few major adipokines which played their major role in Atrial Fibrillation. The review article did not limit the time frame. Conclusion In conclusion, adipokines play a significant role in the development and progress of atrial fibrillation. Also, there are major adipokines such as adiponectin, apelin, C1q/TNF-Related Protein 3 (CTRP3), Chemerin, Omentin-1, interleukin-6, Leptin, TNF-α, resistin, and interleukin-10, which played their pathophysiological role in atrial fibrillation by causing cardiac hypertrophy, increasing the cardiac contractility and action potential duration, atrial fibrosis, electrical and structural remodeling of atrial tissue.Saira RafaqatSana RafaqatSimon RafaqatBMCarticleAdiponectinApelinC1q/TNF-Related Protein 3ChemerinOmentin-1Interleukin-6Diseases of the circulatory (Cardiovascular) systemRC666-701ENInternational Journal of Arrhythmia, Vol 22, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adiponectin Apelin C1q/TNF-Related Protein 3 Chemerin Omentin-1 Interleukin-6 Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Adiponectin Apelin C1q/TNF-Related Protein 3 Chemerin Omentin-1 Interleukin-6 Diseases of the circulatory (Cardiovascular) system RC666-701 Saira Rafaqat Sana Rafaqat Simon Rafaqat Pathophysiological role of major adipokines in Atrial Fibrillation
description	Abstract Background The adipokines, secreted from adipose tissue or body fats, are also called adipocytokines which are cytokines, cell signaling proteins or cell–cell communication. However, AF is a common cardiac arrhythmia in which the heart beats so fast by abnormal beating and is a serious public health disease associated with increased heart failure, systemic thromboembolism, and death. Adipokines are cardiovascular disease (CVD) mediators or biomarkers that affect the heart as well as blood vessels, by increasing the cardiac contractility and action potential duration, which result in the extent of left ventricular and atrial remodeling. Main body Google Scholar, PubMed, and science direct were used to review the literature. Many keywords were used for searching the literature such as Adipokines, Leptin, Apelin, Adiponectin, Omentin-1, Chemerin, CTRP3, TNF-α, IL-6, IL-10, and AF. According to the literature, much more data are available for numerous adipokines, but this review article only has taken few major adipokines which played their major role in Atrial Fibrillation. The review article did not limit the time frame. Conclusion In conclusion, adipokines play a significant role in the development and progress of atrial fibrillation. Also, there are major adipokines such as adiponectin, apelin, C1q/TNF-Related Protein 3 (CTRP3), Chemerin, Omentin-1, interleukin-6, Leptin, TNF-α, resistin, and interleukin-10, which played their pathophysiological role in atrial fibrillation by causing cardiac hypertrophy, increasing the cardiac contractility and action potential duration, atrial fibrosis, electrical and structural remodeling of atrial tissue.
format	article
author	Saira Rafaqat Sana Rafaqat Simon Rafaqat
author_facet	Saira Rafaqat Sana Rafaqat Simon Rafaqat
author_sort	Saira Rafaqat
title	Pathophysiological role of major adipokines in Atrial Fibrillation
title_short	Pathophysiological role of major adipokines in Atrial Fibrillation
title_full	Pathophysiological role of major adipokines in Atrial Fibrillation
title_fullStr	Pathophysiological role of major adipokines in Atrial Fibrillation
title_full_unstemmed	Pathophysiological role of major adipokines in Atrial Fibrillation
title_sort	pathophysiological role of major adipokines in atrial fibrillation
publisher	BMC
publishDate	2021
url	https://doaj.org/article/508ba2fa3d7d497eb75f72108b328daf
work_keys_str_mv	AT sairarafaqat pathophysiologicalroleofmajoradipokinesinatrialfibrillation AT sanarafaqat pathophysiologicalroleofmajoradipokinesinatrialfibrillation AT simonrafaqat pathophysiologicalroleofmajoradipokinesinatrialfibrillation
_version_	1718442421794111488

Pathophysiological role of major adipokines in Atrial Fibrillation

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