Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits
There is strong genetic evidence for cigarette smoking behaviors, yet little is known on nicotine dependence (ND). Here, the authors perform a genome-wide association study on ND in 58,000 smokers, identifying five genome-wide significant loci.
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Nature Portfolio
2020
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oai:doaj.org-article:508c732e509b4270b0f67aeb1af54d382021-12-02T14:42:47ZExpanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits10.1038/s41467-020-19265-z2041-1723https://doaj.org/article/508c732e509b4270b0f67aeb1af54d382020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19265-zhttps://doaj.org/toc/2041-1723There is strong genetic evidence for cigarette smoking behaviors, yet little is known on nicotine dependence (ND). Here, the authors perform a genome-wide association study on ND in 58,000 smokers, identifying five genome-wide significant loci.Bryan C. QuachMichael J. BrayNathan C. GaddisMengzhen LiuTeemu PalviainenCamelia C. MinicaStephanie ZellersRichard ShervaFazil AlievMichael NothnagelKendra A. YoungJesse A. MarksHannah YoungMegan U. CarnesYuelong GuoAlex WaldropNancy Y. A. SeyMaria T. LandiDaniel W. McNeilDmitriy DrichelLindsay A. FarrerChristina A. MarkunasJacqueline M. VinkJouke-Jan HottengaWilliam G. IaconoHenry R. KranzlerNancy L. SacconeMichael C. NealePamela MaddenMarcella RietschelMary L. MarazitaMatthew McGueHyejung WonGeorg WintererRichard GruczaDanielle M. DickJoel GelernterNeil E. CaporasoTimothy B. BakerDorret I. BoomsmaJaakko KaprioJohn E. HokansonScott VriezeLaura J. BierutEric O. JohnsonDana B. HancockNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Bryan C. Quach Michael J. Bray Nathan C. Gaddis Mengzhen Liu Teemu Palviainen Camelia C. Minica Stephanie Zellers Richard Sherva Fazil Aliev Michael Nothnagel Kendra A. Young Jesse A. Marks Hannah Young Megan U. Carnes Yuelong Guo Alex Waldrop Nancy Y. A. Sey Maria T. Landi Daniel W. McNeil Dmitriy Drichel Lindsay A. Farrer Christina A. Markunas Jacqueline M. Vink Jouke-Jan Hottenga William G. Iacono Henry R. Kranzler Nancy L. Saccone Michael C. Neale Pamela Madden Marcella Rietschel Mary L. Marazita Matthew McGue Hyejung Won Georg Winterer Richard Grucza Danielle M. Dick Joel Gelernter Neil E. Caporaso Timothy B. Baker Dorret I. Boomsma Jaakko Kaprio John E. Hokanson Scott Vrieze Laura J. Bierut Eric O. Johnson Dana B. Hancock Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits |
| description |
There is strong genetic evidence for cigarette smoking behaviors, yet little is known on nicotine dependence (ND). Here, the authors perform a genome-wide association study on ND in 58,000 smokers, identifying five genome-wide significant loci. |
| format |
article |
| author |
Bryan C. Quach Michael J. Bray Nathan C. Gaddis Mengzhen Liu Teemu Palviainen Camelia C. Minica Stephanie Zellers Richard Sherva Fazil Aliev Michael Nothnagel Kendra A. Young Jesse A. Marks Hannah Young Megan U. Carnes Yuelong Guo Alex Waldrop Nancy Y. A. Sey Maria T. Landi Daniel W. McNeil Dmitriy Drichel Lindsay A. Farrer Christina A. Markunas Jacqueline M. Vink Jouke-Jan Hottenga William G. Iacono Henry R. Kranzler Nancy L. Saccone Michael C. Neale Pamela Madden Marcella Rietschel Mary L. Marazita Matthew McGue Hyejung Won Georg Winterer Richard Grucza Danielle M. Dick Joel Gelernter Neil E. Caporaso Timothy B. Baker Dorret I. Boomsma Jaakko Kaprio John E. Hokanson Scott Vrieze Laura J. Bierut Eric O. Johnson Dana B. Hancock |
| author_facet |
Bryan C. Quach Michael J. Bray Nathan C. Gaddis Mengzhen Liu Teemu Palviainen Camelia C. Minica Stephanie Zellers Richard Sherva Fazil Aliev Michael Nothnagel Kendra A. Young Jesse A. Marks Hannah Young Megan U. Carnes Yuelong Guo Alex Waldrop Nancy Y. A. Sey Maria T. Landi Daniel W. McNeil Dmitriy Drichel Lindsay A. Farrer Christina A. Markunas Jacqueline M. Vink Jouke-Jan Hottenga William G. Iacono Henry R. Kranzler Nancy L. Saccone Michael C. Neale Pamela Madden Marcella Rietschel Mary L. Marazita Matthew McGue Hyejung Won Georg Winterer Richard Grucza Danielle M. Dick Joel Gelernter Neil E. Caporaso Timothy B. Baker Dorret I. Boomsma Jaakko Kaprio John E. Hokanson Scott Vrieze Laura J. Bierut Eric O. Johnson Dana B. Hancock |
| author_sort |
Bryan C. Quach |
| title |
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits |
| title_short |
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits |
| title_full |
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits |
| title_fullStr |
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits |
| title_full_unstemmed |
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits |
| title_sort |
expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/508c732e509b4270b0f67aeb1af54d38 |
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