Molecular determinant of the effects of hydrostatic pressure on protein folding stability

Proteins can be both stabilized and destabilized by pressure. Here the authors analyse the factors contributing to both negative and positive protein volume change upon denaturation, and shed light on the molecular determinants allowing proteins to be stable at high pressures.

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Detalles Bibliográficos
Autores principales:	Calvin R. Chen, George I. Makhatadze
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/50911fbe0db5457e8947f0045802ad5f
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spelling	oai:doaj.org-article:50911fbe0db5457e8947f0045802ad5f2021-12-02T17:06:21ZMolecular determinant of the effects of hydrostatic pressure on protein folding stability10.1038/ncomms145612041-1723https://doaj.org/article/50911fbe0db5457e8947f0045802ad5f2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14561https://doaj.org/toc/2041-1723Proteins can be both stabilized and destabilized by pressure. Here the authors analyse the factors contributing to both negative and positive protein volume change upon denaturation, and shed light on the molecular determinants allowing proteins to be stable at high pressures.Calvin R. ChenGeorge I. MakhatadzeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Calvin R. Chen George I. Makhatadze Molecular determinant of the effects of hydrostatic pressure on protein folding stability
description	Proteins can be both stabilized and destabilized by pressure. Here the authors analyse the factors contributing to both negative and positive protein volume change upon denaturation, and shed light on the molecular determinants allowing proteins to be stable at high pressures.
format	article
author	Calvin R. Chen George I. Makhatadze
author_facet	Calvin R. Chen George I. Makhatadze
author_sort	Calvin R. Chen
title	Molecular determinant of the effects of hydrostatic pressure on protein folding stability
title_short	Molecular determinant of the effects of hydrostatic pressure on protein folding stability
title_full	Molecular determinant of the effects of hydrostatic pressure on protein folding stability
title_fullStr	Molecular determinant of the effects of hydrostatic pressure on protein folding stability
title_full_unstemmed	Molecular determinant of the effects of hydrostatic pressure on protein folding stability
title_sort	molecular determinant of the effects of hydrostatic pressure on protein folding stability
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/50911fbe0db5457e8947f0045802ad5f
work_keys_str_mv	AT calvinrchen moleculardeterminantoftheeffectsofhydrostaticpressureonproteinfoldingstability AT georgeimakhatadze moleculardeterminantoftheeffectsofhydrostaticpressureonproteinfoldingstability
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Molecular determinant of the effects of hydrostatic pressure on protein folding stability

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