Molecular determinant of the effects of hydrostatic pressure on protein folding stability

Proteins can be both stabilized and destabilized by pressure. Here the authors analyse the factors contributing to both negative and positive protein volume change upon denaturation, and shed light on the molecular determinants allowing proteins to be stable at high pressures.

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Bibliographic Details
Main Authors: Calvin R. Chen, George I. Makhatadze
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Q
Online Access:https://doaj.org/article/50911fbe0db5457e8947f0045802ad5f
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