The Effect of Anti-Vascular Endothelial Growth Factor on Retinal Microvascular Changes in Diabetic Macular Edema Using Swept-Source Optical Coherence Tomography Angiography

Pear Pongsachareonnont,1 Pulthip Charoenphol,1 Cameron Hurst,2,3 Thanapong Somkijrungroj1 1Vitreoretinal Research Unit, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; 2Biostatistics Cente...

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Autores principales:	Pongsachareonnont P, Charoenphol P, Hurst C, Somkijrungroj T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetic macular edema diabetic retinopathy foveal avascular zone microaneurysms anti-vegf oct-a Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/50957badf2e34eb8840b7c4ee6b9dc52
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spelling	oai:doaj.org-article:50957badf2e34eb8840b7c4ee6b9dc522021-12-02T12:13:04ZThe Effect of Anti-Vascular Endothelial Growth Factor on Retinal Microvascular Changes in Diabetic Macular Edema Using Swept-Source Optical Coherence Tomography Angiography1177-5483https://doaj.org/article/50957badf2e34eb8840b7c4ee6b9dc522020-11-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-anti-vascular-endothelial-growth-factor-on-retinal-micro-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Pear Pongsachareonnont,1 Pulthip Charoenphol,1 Cameron Hurst,2,3 Thanapong Somkijrungroj1 1Vitreoretinal Research Unit, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; 2Biostatistics Center, Department of Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 3QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaCorrespondence: Pear PongsachareonnontVitreoretinal Research Unit, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, ThailandTel +66-2256-4142Fax +66-2-252-8290Email pear.p@chulahospital.orgPurpose: This study evaluates the effect of anti-vascular endothelial growth factor (anti-VEGF) therapy on microaneurysm changes and foveal avascular zone (FAZ) using optical coherence tomography angiography (OCTA) in patients with diabetic macular edema (DME).Design: Prospective observational study.Materials and Methods: This study involved patients with DME undergoing anti-VEGF treatment (aflibercept, ranibizumab, and bevacizumab). Macula OCTA images were obtained before (visit 0) and 1 month after (visit 1) anti-VEGF injection. Microaneurysm counts were performed, and the FAZ was evaluated in the superficial capillary plexus (SCP) and deep capillary plexus (DCP). The differences in microaneurysms, FAZ, and clinical correlations were analyzed.Results: A total of 152 eyes were analyzed. The patients’ mean age was 59 years. Bevacizumab was used in 69.7%, ranibizumab in 15.1%, and aflibercept in 15.1%. There was a significant reduction in the FAZ in the SCP and DCP between visits 0 and 1. All anti-VEGF medications reduced the number of microaneurysms (p< 0.01). After treatment, changes in the FAZ in SCP and DCP corresponded with changes in visual acuity (p< 0.01).Conclusion: Microaneurysms as detected by OCTA might serve as a biomarker for a clinical response to anti-VEGF treatment in the short term. The FAZ might also predict visual acuity improvement after anti-VEGF injection.Trial Registration: Thai Clinical Trials Registry (TCTR20161010005).Keywords: diabetic macular edema, diabetic retinopathy, foveal avascular zone, microaneurysms, anti-VEGF, OCT-APongsachareonnont PCharoenphol PHurst CSomkijrungroj TDove Medical Pressarticlediabetic macular edema diabetic retinopathy foveal avascular zone microaneurysms anti-vegf oct-aOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3871-3880 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic macular edema diabetic retinopathy foveal avascular zone microaneurysms anti-vegf oct-a Ophthalmology RE1-994
spellingShingle	diabetic macular edema diabetic retinopathy foveal avascular zone microaneurysms anti-vegf oct-a Ophthalmology RE1-994 Pongsachareonnont P Charoenphol P Hurst C Somkijrungroj T The Effect of Anti-Vascular Endothelial Growth Factor on Retinal Microvascular Changes in Diabetic Macular Edema Using Swept-Source Optical Coherence Tomography Angiography
description	Pear Pongsachareonnont,1 Pulthip Charoenphol,1 Cameron Hurst,2,3 Thanapong Somkijrungroj1 1Vitreoretinal Research Unit, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; 2Biostatistics Center, Department of Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 3QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaCorrespondence: Pear PongsachareonnontVitreoretinal Research Unit, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathumwan, Bangkok 10330, ThailandTel +66-2256-4142Fax +66-2-252-8290Email pear.p@chulahospital.orgPurpose: This study evaluates the effect of anti-vascular endothelial growth factor (anti-VEGF) therapy on microaneurysm changes and foveal avascular zone (FAZ) using optical coherence tomography angiography (OCTA) in patients with diabetic macular edema (DME).Design: Prospective observational study.Materials and Methods: This study involved patients with DME undergoing anti-VEGF treatment (aflibercept, ranibizumab, and bevacizumab). Macula OCTA images were obtained before (visit 0) and 1 month after (visit 1) anti-VEGF injection. Microaneurysm counts were performed, and the FAZ was evaluated in the superficial capillary plexus (SCP) and deep capillary plexus (DCP). The differences in microaneurysms, FAZ, and clinical correlations were analyzed.Results: A total of 152 eyes were analyzed. The patients’ mean age was 59 years. Bevacizumab was used in 69.7%, ranibizumab in 15.1%, and aflibercept in 15.1%. There was a significant reduction in the FAZ in the SCP and DCP between visits 0 and 1. All anti-VEGF medications reduced the number of microaneurysms (p< 0.01). After treatment, changes in the FAZ in SCP and DCP corresponded with changes in visual acuity (p< 0.01).Conclusion: Microaneurysms as detected by OCTA might serve as a biomarker for a clinical response to anti-VEGF treatment in the short term. The FAZ might also predict visual acuity improvement after anti-VEGF injection.Trial Registration: Thai Clinical Trials Registry (TCTR20161010005).Keywords: diabetic macular edema, diabetic retinopathy, foveal avascular zone, microaneurysms, anti-VEGF, OCT-A
format	article
author	Pongsachareonnont P Charoenphol P Hurst C Somkijrungroj T
author_facet	Pongsachareonnont P Charoenphol P Hurst C Somkijrungroj T
author_sort	Pongsachareonnont P
title	The Effect of Anti-Vascular Endothelial Growth Factor on Retinal Microvascular Changes in Diabetic Macular Edema Using Swept-Source Optical Coherence Tomography Angiography
title_short	The Effect of Anti-Vascular Endothelial Growth Factor on Retinal Microvascular Changes in Diabetic Macular Edema Using Swept-Source Optical Coherence Tomography Angiography
title_full	The Effect of Anti-Vascular Endothelial Growth Factor on Retinal Microvascular Changes in Diabetic Macular Edema Using Swept-Source Optical Coherence Tomography Angiography
title_fullStr	The Effect of Anti-Vascular Endothelial Growth Factor on Retinal Microvascular Changes in Diabetic Macular Edema Using Swept-Source Optical Coherence Tomography Angiography
title_full_unstemmed	The Effect of Anti-Vascular Endothelial Growth Factor on Retinal Microvascular Changes in Diabetic Macular Edema Using Swept-Source Optical Coherence Tomography Angiography
title_sort	effect of anti-vascular endothelial growth factor on retinal microvascular changes in diabetic macular edema using swept-source optical coherence tomography angiography
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/50957badf2e34eb8840b7c4ee6b9dc52
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The Effect of Anti-Vascular Endothelial Growth Factor on Retinal Microvascular Changes in Diabetic Macular Edema Using Swept-Source Optical Coherence Tomography Angiography

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