The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm

Yero et al. elucidate the function of Ttg2D, a Pseudomonas aeruginosa periplasmic protein, in maintaining phospholipid asymmetry between the outer and inner membrane. Gram negative bacteria have inner and outer membranes that differ in phospholipd composition. Using X-ray crystallography and mass sp...

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Autores principales:	Daniel Yero, Mireia Díaz-Lobo, Lionel Costenaro, Oscar Conchillo-Solé, Adrià Mayo, Mario Ferrer-Navarro, Marta Vilaseca, Isidre Gibert, Xavier Daura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/50977891a64d4ef6a08754ef5a6e7656
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spelling	oai:doaj.org-article:50977891a64d4ef6a08754ef5a6e76562021-12-02T18:15:09ZThe Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm10.1038/s42003-021-01968-82399-3642https://doaj.org/article/50977891a64d4ef6a08754ef5a6e76562021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01968-8https://doaj.org/toc/2399-3642Yero et al. elucidate the function of Ttg2D, a Pseudomonas aeruginosa periplasmic protein, in maintaining phospholipid asymmetry between the outer and inner membrane. Gram negative bacteria have inner and outer membranes that differ in phospholipd composition. Using X-ray crystallography and mass spectrometry, the authors show that Ttg2D can carry two diacyl glycerophospholipids or a cardiolipin. The authors also identify a role for Ttg2D in resistance against antibiotics that use a lipid-mediated pathway into the cell.Daniel YeroMireia Díaz-LoboLionel CostenaroOscar Conchillo-SoléAdrià MayoMario Ferrer-NavarroMarta VilasecaIsidre GibertXavier DauraNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Daniel Yero Mireia Díaz-Lobo Lionel Costenaro Oscar Conchillo-Solé Adrià Mayo Mario Ferrer-Navarro Marta Vilaseca Isidre Gibert Xavier Daura The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
description	Yero et al. elucidate the function of Ttg2D, a Pseudomonas aeruginosa periplasmic protein, in maintaining phospholipid asymmetry between the outer and inner membrane. Gram negative bacteria have inner and outer membranes that differ in phospholipd composition. Using X-ray crystallography and mass spectrometry, the authors show that Ttg2D can carry two diacyl glycerophospholipids or a cardiolipin. The authors also identify a role for Ttg2D in resistance against antibiotics that use a lipid-mediated pathway into the cell.
format	article
author	Daniel Yero Mireia Díaz-Lobo Lionel Costenaro Oscar Conchillo-Solé Adrià Mayo Mario Ferrer-Navarro Marta Vilaseca Isidre Gibert Xavier Daura
author_facet	Daniel Yero Mireia Díaz-Lobo Lionel Costenaro Oscar Conchillo-Solé Adrià Mayo Mario Ferrer-Navarro Marta Vilaseca Isidre Gibert Xavier Daura
author_sort	Daniel Yero
title	The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
title_short	The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
title_full	The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
title_fullStr	The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
title_full_unstemmed	The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
title_sort	pseudomonas aeruginosa substrate-binding protein ttg2d functions as a general glycerophospholipid transporter across the periplasm
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/50977891a64d4ef6a08754ef5a6e7656
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The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm

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