Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex

Background: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive tool commonly used to drive neural plasticity in the young adult and aged brain. Recent data from mouse models have shown that even at subthreshold intensities (0.12 T), rTMS can drive neuronal and glial plasticity in...

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Autores principales:	Alexander D. Tang, William Bennett, Aidan D. Bindoff, Samuel Bolland, Jessica Collins, Ross C. Langley, Michael I. Garry, Jeffery J. Summers, Mark R. Hinder, Jennifer Rodger, Alison J. Canty
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Repetitive transcranial magnetic stimulation Intermittent theta burst stimulation Structural synaptic plasticity Motor cortex Ageing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/5097fd00807a4a2a925803097f3aef7e
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spelling	oai:doaj.org-article:5097fd00807a4a2a925803097f3aef7e2021-11-20T04:58:34ZSubthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex1935-861X10.1016/j.brs.2021.10.001https://doaj.org/article/5097fd00807a4a2a925803097f3aef7e2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1935861X21002473https://doaj.org/toc/1935-861XBackground: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive tool commonly used to drive neural plasticity in the young adult and aged brain. Recent data from mouse models have shown that even at subthreshold intensities (0.12 T), rTMS can drive neuronal and glial plasticity in the motor cortex. However, the physiological mechanisms underlying subthreshold rTMS induced plasticity and whether these are altered with normal ageing are unclear. Objective: To assess the effect of subthreshold rTMS, using the intermittent theta burst stimulation (iTBS) protocol on structural synaptic plasticity in the mouse motor cortex of young and aged mice. Methods: Longitudinal in vivo 2-photon microscopy was used to measure changes to the structural plasticity of pyramidal neuron dendritic spines in the motor cortex following a single train of subthreshold rTMS (in young adult and aged animals) or the same rTMS train administered on 4 consecutive days (in young adult animals only). Data were analysed with Bayesian hierarchical generalized linear regression models and interpreted with the aid of Bayes Factors (BF). Results: We found strong evidence (BF > 10) that subthreshold rTMS altered the rate of dendritic spine losses and gains, dependent on the number of stimulation sessions and that a single session of subthreshold rTMS was effective in driving structural synaptic plasticity in both young adult and aged mice. Conclusion: These findings provide further evidence that rTMS drives synaptic plasticity in the brain and uncovers structural synaptic plasticity as a key mechanism of subthreshold rTMS induced plasticity.Alexander D. TangWilliam BennettAidan D. BindoffSamuel BollandJessica CollinsRoss C. LangleyMichael I. GarryJeffery J. SummersMark R. HinderJennifer RodgerAlison J. CantyElsevierarticleRepetitive transcranial magnetic stimulationIntermittent theta burst stimulationStructural synaptic plasticityMotor cortexAgeingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Stimulation, Vol 14, Iss 6, Pp 1498-1507 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Repetitive transcranial magnetic stimulation Intermittent theta burst stimulation Structural synaptic plasticity Motor cortex Ageing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Repetitive transcranial magnetic stimulation Intermittent theta burst stimulation Structural synaptic plasticity Motor cortex Ageing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Alexander D. Tang William Bennett Aidan D. Bindoff Samuel Bolland Jessica Collins Ross C. Langley Michael I. Garry Jeffery J. Summers Mark R. Hinder Jennifer Rodger Alison J. Canty Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
description	Background: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive tool commonly used to drive neural plasticity in the young adult and aged brain. Recent data from mouse models have shown that even at subthreshold intensities (0.12 T), rTMS can drive neuronal and glial plasticity in the motor cortex. However, the physiological mechanisms underlying subthreshold rTMS induced plasticity and whether these are altered with normal ageing are unclear. Objective: To assess the effect of subthreshold rTMS, using the intermittent theta burst stimulation (iTBS) protocol on structural synaptic plasticity in the mouse motor cortex of young and aged mice. Methods: Longitudinal in vivo 2-photon microscopy was used to measure changes to the structural plasticity of pyramidal neuron dendritic spines in the motor cortex following a single train of subthreshold rTMS (in young adult and aged animals) or the same rTMS train administered on 4 consecutive days (in young adult animals only). Data were analysed with Bayesian hierarchical generalized linear regression models and interpreted with the aid of Bayes Factors (BF). Results: We found strong evidence (BF > 10) that subthreshold rTMS altered the rate of dendritic spine losses and gains, dependent on the number of stimulation sessions and that a single session of subthreshold rTMS was effective in driving structural synaptic plasticity in both young adult and aged mice. Conclusion: These findings provide further evidence that rTMS drives synaptic plasticity in the brain and uncovers structural synaptic plasticity as a key mechanism of subthreshold rTMS induced plasticity.
format	article
author	Alexander D. Tang William Bennett Aidan D. Bindoff Samuel Bolland Jessica Collins Ross C. Langley Michael I. Garry Jeffery J. Summers Mark R. Hinder Jennifer Rodger Alison J. Canty
author_facet	Alexander D. Tang William Bennett Aidan D. Bindoff Samuel Bolland Jessica Collins Ross C. Langley Michael I. Garry Jeffery J. Summers Mark R. Hinder Jennifer Rodger Alison J. Canty
author_sort	Alexander D. Tang
title	Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
title_short	Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
title_full	Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
title_fullStr	Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
title_full_unstemmed	Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
title_sort	subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5097fd00807a4a2a925803097f3aef7e
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Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex

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