Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators

Bacterially encoded environmental sensor proteins are potentially a rich source of transcriptional control but only a few have been harnessed for biotechnological applications. Here the authors develop a general strategy for designing custom-made monogenic synthetic sensors and validate the approach...

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Auteurs principaux:	Javier F. Juárez, Begoña Lecube-Azpeitia, Stuart L. Brown, Christopher D. Johnston, George M. Church
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/50a00b50b5a94dd387731b478a9443ee
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id	oai:doaj.org-article:50a00b50b5a94dd387731b478a9443ee
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spelling	oai:doaj.org-article:50a00b50b5a94dd387731b478a9443ee2021-12-02T16:49:18ZBiosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators10.1038/s41467-018-05525-62041-1723https://doaj.org/article/50a00b50b5a94dd387731b478a9443ee2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05525-6https://doaj.org/toc/2041-1723Bacterially encoded environmental sensor proteins are potentially a rich source of transcriptional control but only a few have been harnessed for biotechnological applications. Here the authors develop a general strategy for designing custom-made monogenic synthetic sensors and validate the approach by designing two sense-and-respond regulators for benzoate.Javier F. JuárezBegoña Lecube-AzpeitiaStuart L. BrownChristopher D. JohnstonGeorge M. ChurchNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Javier F. Juárez Begoña Lecube-Azpeitia Stuart L. Brown Christopher D. Johnston George M. Church Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators
description	Bacterially encoded environmental sensor proteins are potentially a rich source of transcriptional control but only a few have been harnessed for biotechnological applications. Here the authors develop a general strategy for designing custom-made monogenic synthetic sensors and validate the approach by designing two sense-and-respond regulators for benzoate.
format	article
author	Javier F. Juárez Begoña Lecube-Azpeitia Stuart L. Brown Christopher D. Johnston George M. Church
author_facet	Javier F. Juárez Begoña Lecube-Azpeitia Stuart L. Brown Christopher D. Johnston George M. Church
author_sort	Javier F. Juárez
title	Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators
title_short	Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators
title_full	Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators
title_fullStr	Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators
title_full_unstemmed	Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators
title_sort	biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/50a00b50b5a94dd387731b478a9443ee
work_keys_str_mv	AT javierfjuarez biosensorlibrariesharnesslargeclassesofbindingdomainsforconstructionofallosterictranscriptionalregulators AT begonalecubeazpeitia biosensorlibrariesharnesslargeclassesofbindingdomainsforconstructionofallosterictranscriptionalregulators AT stuartlbrown biosensorlibrariesharnesslargeclassesofbindingdomainsforconstructionofallosterictranscriptionalregulators AT christopherdjohnston biosensorlibrariesharnesslargeclassesofbindingdomainsforconstructionofallosterictranscriptionalregulators AT georgemchurch biosensorlibrariesharnesslargeclassesofbindingdomainsforconstructionofallosterictranscriptionalregulators
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Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators

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