Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators

Bacterially encoded environmental sensor proteins are potentially a rich source of transcriptional control but only a few have been harnessed for biotechnological applications. Here the authors develop a general strategy for designing custom-made monogenic synthetic sensors and validate the approach...

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Bibliographic Details
Main Authors: Javier F. Juárez, Begoña Lecube-Azpeitia, Stuart L. Brown, Christopher D. Johnston, George M. Church
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/50a00b50b5a94dd387731b478a9443ee
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